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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why Does Testosterone Increase Blood Thickness?
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<blockquote data-quote="madman" data-source="post: 132022" data-attributes="member: 13851"><p><span style="font-size: 18px"><strong>Results</strong></span></p><p></p><p>For men undergoing TTh, the risk of developing erythrocytosis compared with controls is well established, with short-acting injectable formulations having the highest associated incidence. Potential mechanisms explaining the relation between TTh and erythrocytosis include the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/role-playing" target="_blank">role</a> of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hepcidin" target="_blank">hepcidin</a>, iron sequestration and turnover, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/erythropoietin" target="_blank">erythropoietin</a> production, <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/bone-marrow" target="_blank">bone marrow</a> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/stimulation" target="_blank">stimulation</a>, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/heredity" target="_blank">genetic factors</a>. High blood viscosity increases the risk for potential vascular complications involving the coronary, cerebrovascular, and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/peripheral-circulation" target="_blank">peripheral vascular circulations</a>, although there is limited evidence supporting a relation between TTh and vascular complications.</p><p></p><p></p><p><a href="https://www.sciencedirect.com/science/article/pii/S2050052117300410?via%3Dihub#fig1" target="_blank">Figure 1</a> <strong>illustrates the proposed direct and indirect effects of T on erythropoiesis. </strong></p><p>[ATTACH=full]6487[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="font-size: 22px"><strong>Conclusions</strong></span></p><p></p><p><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/erythrocytosis" target="_blank">Erythrocytosis</a> is often a limiting variable in patients on TTh. <strong><span style="color: rgb(184, 49, 47)">Direct and indirect effects related to supraphysiologic T levels are believed to mediate the effects on erythrocytosis</span></strong>. The true mechanism of erythrocytosis and its <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/role-playing" target="_blank">role</a> in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/thromboembolism" target="_blank">thromboembolic</a> events remain unclear, although some data support an increased risk of CV events resulting from T-induced erythrocytosis. Large multicenter randomized controlled trials are required to study TTh, its effects on Hb and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/hematocrit" target="_blank">Hct</a>, and the clinical significance of treatment-induced increases in red blood cell mass.</p></blockquote><p></p>
[QUOTE="madman, post: 132022, member: 13851"] [SIZE=18px][B]Results[/B][/SIZE] For men undergoing TTh, the risk of developing erythrocytosis compared with controls is well established, with short-acting injectable formulations having the highest associated incidence. Potential mechanisms explaining the relation between TTh and erythrocytosis include the [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/role-playing']role[/URL] of [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/hepcidin']hepcidin[/URL], iron sequestration and turnover, [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/erythropoietin']erythropoietin[/URL] production, [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/bone-marrow']bone marrow[/URL] [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/stimulation']stimulation[/URL], and [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/heredity']genetic factors[/URL]. High blood viscosity increases the risk for potential vascular complications involving the coronary, cerebrovascular, and [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/peripheral-circulation']peripheral vascular circulations[/URL], although there is limited evidence supporting a relation between TTh and vascular complications. [URL='https://www.sciencedirect.com/science/article/pii/S2050052117300410?via%3Dihub#fig1']Figure 1[/URL] [B]illustrates the proposed direct and indirect effects of T on erythropoiesis. [/B] [ATTACH=full]6487[/ATTACH] [SIZE=22px][B]Conclusions[/B][/SIZE] [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/erythrocytosis']Erythrocytosis[/URL] is often a limiting variable in patients on TTh. [B][COLOR=rgb(184, 49, 47)]Direct and indirect effects related to supraphysiologic T levels are believed to mediate the effects on erythrocytosis[/COLOR][/B]. The true mechanism of erythrocytosis and its [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/role-playing']role[/URL] in [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/thromboembolism']thromboembolic[/URL] events remain unclear, although some data support an increased risk of CV events resulting from T-induced erythrocytosis. Large multicenter randomized controlled trials are required to study TTh, its effects on Hb and [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/hematocrit']Hct[/URL], and the clinical significance of treatment-induced increases in red blood cell mass. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why Does Testosterone Increase Blood Thickness?
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