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Skin becomes inflamed, feels irritated to the touch and breaks out with acne.

Fasting glucose, fasting insulin, HbA1c, lipid panel (watch triglyceride:HDL ratio), uric acid (driven up by fructose, both a marker for and cause of metabolic dysfunction), and ALT / AST / GGT (screen for liver harm by fructose).  Don't forget oxidized LDL as a measure of oxidative stress and causative agent of atherosclerosis (native LDL is inert).