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Some of them disappear, yes. Tolerance builds to the stimulant effects, and associated side effects, including anxiety, fast heart rate, insomnia, etc. Dose-limiting side effects for me have been cognitive impairment with high doses of prop (20+ mg), particularly in the middle of the workday around peak levels, and aggravation of GERD symptoms. No tolerance seems to develop to these.I think there are two flavors of cognitive impairment you can experience with TRT: a direct effect of supraphysiologic levels, and indirect effects via sleep disruption. I think what I was experiencing when I previously quit TRT was the sleep disruption variety, because my dose was not high at all back then (70 - 100 mg weekly). I have since had periods of good cognition with higher doses, as long as my sleep quality was good.
Some of them disappear, yes. Tolerance builds to the stimulant effects, and associated side effects, including anxiety, fast heart rate, insomnia, etc. Dose-limiting side effects for me have been cognitive impairment with high doses of prop (20+ mg), particularly in the middle of the workday around peak levels, and aggravation of GERD symptoms. No tolerance seems to develop to these.
I think there are two flavors of cognitive impairment you can experience with TRT: a direct effect of supraphysiologic levels, and indirect effects via sleep disruption. I think what I was experiencing when I previously quit TRT was the sleep disruption variety, because my dose was not high at all back then (70 - 100 mg weekly). I have since had periods of good cognition with higher doses, as long as my sleep quality was good.
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