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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Why Clomid Fails: The Zuclomiphene Threshold
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 74048" data-attributes="member: 12687"><p>I've used tamoxifen for HPTA stimulation in many guys (though not as many as clomid) with overall varying results, but somewhat less potent than clomid with HPTA stimulation. </p><p></p><p>We have to not only think of the zuclomiphene effect (which is relevant and also specific to clomid), but also the interaction with central E2 receptors (in the brain) of any and ALL SERMS. This interaction with the E receptors is likely to play an equal or greater role in impacting libido than even the zuclomiphene effect. Variable interactions with receptors (agonist/antagonist) can explain why some guys have a good libido response to clomid, while others have a horrible libido response to clomid (much like some guys have great libido at lower E2 levels and others have great libido at higher E2 levels).</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 74048, member: 12687"] I've used tamoxifen for HPTA stimulation in many guys (though not as many as clomid) with overall varying results, but somewhat less potent than clomid with HPTA stimulation. We have to not only think of the zuclomiphene effect (which is relevant and also specific to clomid), but also the interaction with central E2 receptors (in the brain) of any and ALL SERMS. This interaction with the E receptors is likely to play an equal or greater role in impacting libido than even the zuclomiphene effect. Variable interactions with receptors (agonist/antagonist) can explain why some guys have a good libido response to clomid, while others have a horrible libido response to clomid (much like some guys have great libido at lower E2 levels and others have great libido at higher E2 levels). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Why Clomid Fails: The Zuclomiphene Threshold
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