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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Why Clomid Fails: The Zuclomiphene Threshold
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<blockquote data-quote="socks" data-source="post: 38106" data-attributes="member: 13240"><p>There are many variables (severe understatement) to predicting an individuals reaction. The only way to know is by individual experimentation. This does <em>not</em> however mean we cannot make more informed decisions based on research to create potentially ideal dosing/timing/elimination for an optimal end result. In part three, I'll discuss more about potential avenues of dosing/timing and ancillaries that could result in better outcomes.</p><p></p><p>Key Variables: </p><p>1) Hepatic(liver) metabolism of clomiphene into it's "active" metabolites within the body can vary greatly due to individual genetic <a href="https://en.wikipedia.org/wiki/Polymorphism_%28biology%29" target="_blank">polymorphisms</a> of the key cytochrome enzyme(CYP2D6) involved in clomiphene metabolism. Also, competitive metabolism with e2 can increase serum e2 levels or delay clomid metabolite clearance. The latter obviously being an issue since the Z-isomer hangs around longer in our systems and unopposed by the E-isomer(leaves system quicker) the Z-isomer can start to cause issues.</p><p></p><p>2)Excretion/elimination of the Z-isomer(zuclomiphene) is slow for most and even slower in others. It's accumulation in tissues can happen faster in some patients because <em>it's simply not excreted as fast</em> <a href="http://hmg.oxfordjournals.org/content/21/5/1145.long" target="_blank">(3)</a>. As such, some will approach their Zuclomiphene threshold slowly or rapidly, <strong>or never</strong> because they do not have as many ER in certain brain regions or metabolize the Z-isomer so quickly it cannot causes issues (the former being a more likely scenario).</p></blockquote><p></p>
[QUOTE="socks, post: 38106, member: 13240"] There are many variables (severe understatement) to predicting an individuals reaction. The only way to know is by individual experimentation. This does [I]not[/I] however mean we cannot make more informed decisions based on research to create potentially ideal dosing/timing/elimination for an optimal end result. In part three, I'll discuss more about potential avenues of dosing/timing and ancillaries that could result in better outcomes. Key Variables: 1) Hepatic(liver) metabolism of clomiphene into it's "active" metabolites within the body can vary greatly due to individual genetic [URL="https://en.wikipedia.org/wiki/Polymorphism_%28biology%29"]polymorphisms[/URL] of the key cytochrome enzyme(CYP2D6) involved in clomiphene metabolism. Also, competitive metabolism with e2 can increase serum e2 levels or delay clomid metabolite clearance. The latter obviously being an issue since the Z-isomer hangs around longer in our systems and unopposed by the E-isomer(leaves system quicker) the Z-isomer can start to cause issues. 2)Excretion/elimination of the Z-isomer(zuclomiphene) is slow for most and even slower in others. It's accumulation in tissues can happen faster in some patients because [I]it's simply not excreted as fast[/I] [URL="http://hmg.oxfordjournals.org/content/21/5/1145.long"](3)[/URL]. As such, some will approach their Zuclomiphene threshold slowly or rapidly, [B]or never[/B] because they do not have as many ER in certain brain regions or metabolize the Z-isomer so quickly it cannot causes issues (the former being a more likely scenario). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Why Clomid Fails: The Zuclomiphene Threshold
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