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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why can’t all major labs standardize and ranges?
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<blockquote data-quote="madman" data-source="post: 170098" data-attributes="member: 13851"><p>It is happening as we speak and is being undertaken by the Centers for Disease Control and Prevention (CDC) and Partnership for the Accurate Testing of Hormones (PATH).</p><p></p><p><strong>CDC Laboratory/Manufacturer Hormone Standardization <span style="color: rgb(184, 49, 47)">(HoSt) </span>Program </strong></p><p></p><p>Standardization of Total Testosterone and Estradiol are already in practice and Free Testosterone is just a matter of time.</p><p></p><p>[ATTACH=full]9109[/ATTACH]</p><p></p><p>Regarding harmonized reference ranges only Total Testosterone (250-916 ng/dL) has been done so far.....mind you it has not been implemented across all major labs as of yet.</p><p></p><p>Harmonized reference ranges for Free Testosterone and Estradiol are in the works and it is just a matter of time.</p><p></p><p>How long it will take before the harmonized reference ranges will be implemented across all the major labs.....hard to say but should be within the next year or two.</p><p></p><p>[ATTACH=full]9111[/ATTACH]</p><p></p><p></p><p>[ATTACH=full]9110[/ATTACH]</p><p></p><p>How long it will take before the harmonized reference ranges will be implemented at the major labs.....hard to say but should be within the next year or two.</p><p></p><p>Best piece of advice for now is to have your blood work done at the <strong>same lab</strong> using the <strong>same testing method</strong> and most importantly <strong>test at the proper time <span style="color: rgb(184, 49, 47)">(trough)</span></strong>.....keep your <span style="color: rgb(184, 49, 47)"><strong>protocol consistent</strong></span><strong> (dose/injection frequency/<span style="color: rgb(184, 49, 47)"><strong>timing of injections</strong></span>)</strong> as any deviation in such will skew test results when comparing your blood work.</p><p></p><p></p><p></p><p></p><p>If you are seeking the most accurate testing methods:</p><p></p><p><strong>Total Testosterone: <span style="color: rgb(184, 49, 47)">Liquid chromatography/tandem mass spectrometry (LC/MS-MS) </span><span style="color: rgb(250, 197, 28)">(gold standard)</span></strong></p><p></p><p><strong>Estradiol: </strong><span style="color: rgb(184, 49, 47)"><strong>Estradiol, Sensitive, Liquid chromatography/tandem mass spectrometry (LC/MS-MS) </strong></span></p><p></p><p><strong>Free Testosterone:</strong> <strong><span style="color: rgb(184, 49, 47)">Equilibrium Dialysis </span><span style="color: rgb(250, 197, 28)">(gold standard)</span> </strong><span style="color: rgb(0, 0, 0)">or </span><strong><span style="color: rgb(184, 49, 47)">Ultrafiltration </span></strong></p><p></p><p>If you choose to use a calculated method than stick to the <strong><span style="color: rgb(184, 49, 47)">TruT </span></strong><span style="color: rgb(0, 0, 0)">calculator: </span></p><p><a href="https://tru-t.org/" target="_blank">Click here</a> for access to the free TruT public calculator.</p><p></p><p></p><p></p><p></p><p>Now for Total Testosterone and Estradiol testing we can nit pick here but regarding Free Testosterone the testing method is critical.</p></blockquote><p></p>
[QUOTE="madman, post: 170098, member: 13851"] It is happening as we speak and is being undertaken by the Centers for Disease Control and Prevention (CDC) and Partnership for the Accurate Testing of Hormones (PATH). [B]CDC Laboratory/Manufacturer Hormone Standardization [COLOR=rgb(184, 49, 47)](HoSt) [/COLOR]Program [/B] Standardization of Total Testosterone and Estradiol are already in practice and Free Testosterone is just a matter of time. [ATTACH=full]9109[/ATTACH] Regarding harmonized reference ranges only Total Testosterone (250-916 ng/dL) has been done so far.....mind you it has not been implemented across all major labs as of yet. Harmonized reference ranges for Free Testosterone and Estradiol are in the works and it is just a matter of time. How long it will take before the harmonized reference ranges will be implemented across all the major labs.....hard to say but should be within the next year or two. [ATTACH=full]9111[/ATTACH] [ATTACH=full]9110[/ATTACH] How long it will take before the harmonized reference ranges will be implemented at the major labs.....hard to say but should be within the next year or two. Best piece of advice for now is to have your blood work done at the [B]same lab[/B] using the [B]same testing method[/B] and most importantly [B]test at the proper time [COLOR=rgb(184, 49, 47)](trough)[/COLOR][/B].....keep your [COLOR=rgb(184, 49, 47)][B]protocol consistent[/B][/COLOR][B] (dose/injection frequency/[COLOR=rgb(184, 49, 47)][B]timing of injections[/B][/COLOR])[/B] as any deviation in such will skew test results when comparing your blood work. If you are seeking the most accurate testing methods: [B]Total Testosterone: [COLOR=rgb(184, 49, 47)]Liquid chromatography/tandem mass spectrometry (LC/MS-MS) [/COLOR][COLOR=rgb(250, 197, 28)](gold standard)[/COLOR][/B] [B]Estradiol: [/B][COLOR=rgb(184, 49, 47)][B]Estradiol, Sensitive, Liquid chromatography/tandem mass spectrometry (LC/MS-MS) [/B][/COLOR] [B]Free Testosterone:[/B] [B][COLOR=rgb(184, 49, 47)]Equilibrium Dialysis [/COLOR][COLOR=rgb(250, 197, 28)](gold standard)[/COLOR] [/B][COLOR=rgb(0, 0, 0)]or [/COLOR][B][COLOR=rgb(184, 49, 47)]Ultrafiltration [/COLOR][/B] If you choose to use a calculated method than stick to the [B][COLOR=rgb(184, 49, 47)]TruT [/COLOR][/B][COLOR=rgb(0, 0, 0)]calculator: [/COLOR] [URL='https://tru-t.org/']Click here[/URL] for access to the free TruT public calculator. Now for Total Testosterone and Estradiol testing we can nit pick here but regarding Free Testosterone the testing method is critical. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why can’t all major labs standardize and ranges?
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