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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Why All Men Should be Tested with the Sensitive Estradiol Test
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<blockquote data-quote="DragonBits" data-source="post: 103114" data-attributes="member: 18023"><p>From the LEF site:</p><p>“The LC-MS estradiol test is primarily suggested for situations with very low estrogen levels. It can also be used to monitor E2 levels in both men and woman and may be more accurate compared to immunoassays of estradiol; however, Life Extension® has found the majority of customers do not need this more costly test to get adequate information from the regular immunoassay estradiol test.”</p><p> </p><p>LEF doesn’t say they are the same, only that MOST people get ADEQUATE information from the standard test.</p><p> </p><p>What I really HATE is the loose wording most companies use on their documentation. What is LOW ESTROGEN? What is MOST? What is ADEQUATE?</p><p> </p><p>This isn’t just LEF, it’s widespread everywhere. Because it’s far easier to write LOW rather than give an actual pg/mL level that DEFINES low estrogen.</p><p> </p><p>When I was more naïve, I thought the sensitive test would be able to give me information about estrogen levels below 5 pg/mL.</p><p> </p><p>Not what they mean at all, all test Labs use similar loose wording (not just LEF) and LOW is below somewhere around 35.0 pg/ml, which would be many if not the bulk of men. </p><p> </p><p>So, the sensitive test is more ACCURATE probably for the majority of men.</p><p> </p><p>Standard E2test range 7.6-42.6 (For men)</p><p>Sensitive E2 test range 8.0 - 35.0 (for men)</p><p> </p><p>If E2 was close to zero, it would be possible I have an aromatase deficiency, though I doubt it because my E2 was 27.6 pg/ml when I was taking Clomid.</p><p> </p><p>When I do get the sensitive E2 test, several months will have passed, I won’t be able to compare the two tests, but assuming my FT is about the same, I would expect my E2 is about the same. I will be pleasantly surprised if either FT or E2 is higher.</p><p> </p><p>Once you start exogenous testosterone (TRT) I would expect many hormone levels will be moving around in somewhat unpredictable ways and timeframes. For instance. SHBG not only binds with testosterone, it also binds with estrogen. So, I guess lower SGBG levels should mean higher estrogen and higher FT. There are so many feedback loops it seems to me it will take a while to regain a new balance under TRT. I am guessing a while means 1-2 years.</p><p> </p><p>BTW, I am not taking a side here, just chatting about the complexity of hormones in general. I am in favor of getting more accurate information and the sensitive test.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 103114, member: 18023"] From the LEF site: “The LC-MS estradiol test is primarily suggested for situations with very low estrogen levels. It can also be used to monitor E2 levels in both men and woman and may be more accurate compared to immunoassays of estradiol; however, Life Extension® has found the majority of customers do not need this more costly test to get adequate information from the regular immunoassay estradiol test.” LEF doesn’t say they are the same, only that MOST people get ADEQUATE information from the standard test. What I really HATE is the loose wording most companies use on their documentation. What is LOW ESTROGEN? What is MOST? What is ADEQUATE? This isn’t just LEF, it’s widespread everywhere. Because it’s far easier to write LOW rather than give an actual pg/mL level that DEFINES low estrogen. When I was more naïve, I thought the sensitive test would be able to give me information about estrogen levels below 5 pg/mL. Not what they mean at all, all test Labs use similar loose wording (not just LEF) and LOW is below somewhere around 35.0 pg/ml, which would be many if not the bulk of men. So, the sensitive test is more ACCURATE probably for the majority of men. Standard E2test range 7.6-42.6 (For men) Sensitive E2 test range 8.0 - 35.0 (for men) If E2 was close to zero, it would be possible I have an aromatase deficiency, though I doubt it because my E2 was 27.6 pg/ml when I was taking Clomid. When I do get the sensitive E2 test, several months will have passed, I won’t be able to compare the two tests, but assuming my FT is about the same, I would expect my E2 is about the same. I will be pleasantly surprised if either FT or E2 is higher. Once you start exogenous testosterone (TRT) I would expect many hormone levels will be moving around in somewhat unpredictable ways and timeframes. For instance. SHBG not only binds with testosterone, it also binds with estrogen. So, I guess lower SGBG levels should mean higher estrogen and higher FT. There are so many feedback loops it seems to me it will take a while to regain a new balance under TRT. I am guessing a while means 1-2 years. BTW, I am not taking a side here, just chatting about the complexity of hormones in general. I am in favor of getting more accurate information and the sensitive test. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Why All Men Should be Tested with the Sensitive Estradiol Test
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