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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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<blockquote data-quote="HarryCat2" data-source="post: 167382" data-attributes="member: 25152"><p>This paper seems to say that lower SHBG results in higher apparent testosterone metabolic clearance rates.</p><p></p><p><a href="https://academic.oup.com/jcem/article/91/11/4669/2656842" target="_blank"><span style="font-size: 15px"><strong>Differences in the Apparent Metabolic Clearance Rate of Testosterone in Young and Older Men with Gonadotropin Suppression Receiving Graded Doses of Testosterone</strong></span></a></p><p></p><p><span style="font-size: 22px"><strong>Abstract</strong></span></p><p></p><p><strong>Background:</strong> Recently we found that testosterone levels are higher in older men than young men receiving exogenous testosterone. We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels.</p><p></p><p><strong>Objective:</strong> The objective of the study was to compare aMCR-T in older and young men and identify predictors of aMCR-T.</p><p></p><p><strong>Methods:</strong> Sixty-one younger (19–35 yr) and 60 older (59–75 yr) men were given a monthly GnRH agonist and weekly testosterone enanthate (TE) (25, 50, 125, 300, or 600 mg) for 5 months. Estimated aMCR-T was calculated from the amount of TE delivered weekly and trough serum testosterone concentrations, corrected for real-time absorption kinetics from the im testosterone depot.</p><p></p><p><strong>Results:</strong> Older men had lower total (316 ± 13 <em>vs.</em> 585 ± 26 ng/dl, <em>P</em> < 0.00001) and free testosterone (4 ± 0.1 <em>vs.</em> 6 ± 0.3 ng/dl, <em>P</em> < 0.00001) and higher SHBG (52 ± 3 <em>vs.</em> 33 ± 2 nmol/liter, <em>P</em> < 0.00001) than younger men at baseline. Total and free testosterones increased with TE dose and were higher in older men than young men in the 125-, 300-, and 600-mg dose groups. aMCR-T was lower in older men than young men (1390 ± 69 <em>vs.</em> 1821 ± 102 liter/d, <em>P</em> = 0.006). <strong>aMCR-T correlated negatively with age (<em>P</em> = 0.0007), SHBG (<em>P</em> = 0.046)</strong>, and total testosterone during treatment (<em>P</em> = 0.02) and percent body fat at baseline (<em>P</em> = 0.01) and during treatment (<em>P</em> = 0.004). aMCR-T correlated positively with lean body mass at baseline (<em>P</em> = 0.03) and during treatment (<em>P</em> = 0.01). In multiple regression models, significant predictors of aMCR-T included lean body mass (<em>P</em> = 0.008), percent fat mass (<em>P</em> = 0.009), and SHBG (<em>P</em> = 0.001).</p><p></p><p><strong>Conclusions:</strong> Higher testosterone levels in older men receiving TE were associated with an age-related decrease in apparent testosterone metabolic clearance rates. Body composition and SHBG were significant predictors of aMCR-T.</p></blockquote><p></p>
[QUOTE="HarryCat2, post: 167382, member: 25152"] This paper seems to say that lower SHBG results in higher apparent testosterone metabolic clearance rates. [URL='https://academic.oup.com/jcem/article/91/11/4669/2656842'][SIZE=15px][B]Differences in the Apparent Metabolic Clearance Rate of Testosterone in Young and Older Men with Gonadotropin Suppression Receiving Graded Doses of Testosterone[/B][/SIZE][/URL] [SIZE=22px][B]Abstract[/B][/SIZE] [B]Background:[/B] Recently we found that testosterone levels are higher in older men than young men receiving exogenous testosterone. We hypothesized that older men have lower apparent testosterone metabolic clearance rates (aMCR-T) that contribute to higher testosterone levels. [B]Objective:[/B] The objective of the study was to compare aMCR-T in older and young men and identify predictors of aMCR-T. [B]Methods:[/B] Sixty-one younger (19–35 yr) and 60 older (59–75 yr) men were given a monthly GnRH agonist and weekly testosterone enanthate (TE) (25, 50, 125, 300, or 600 mg) for 5 months. Estimated aMCR-T was calculated from the amount of TE delivered weekly and trough serum testosterone concentrations, corrected for real-time absorption kinetics from the im testosterone depot. [B]Results:[/B] Older men had lower total (316 ± 13 [I]vs.[/I] 585 ± 26 ng/dl, [I]P[/I] < 0.00001) and free testosterone (4 ± 0.1 [I]vs.[/I] 6 ± 0.3 ng/dl, [I]P[/I] < 0.00001) and higher SHBG (52 ± 3 [I]vs.[/I] 33 ± 2 nmol/liter, [I]P[/I] < 0.00001) than younger men at baseline. Total and free testosterones increased with TE dose and were higher in older men than young men in the 125-, 300-, and 600-mg dose groups. aMCR-T was lower in older men than young men (1390 ± 69 [I]vs.[/I] 1821 ± 102 liter/d, [I]P[/I] = 0.006). [B]aMCR-T correlated negatively with age ([I]P[/I] = 0.0007), SHBG ([I]P[/I] = 0.046)[/B], and total testosterone during treatment ([I]P[/I] = 0.02) and percent body fat at baseline ([I]P[/I] = 0.01) and during treatment ([I]P[/I] = 0.004). aMCR-T correlated positively with lean body mass at baseline ([I]P[/I] = 0.03) and during treatment ([I]P[/I] = 0.01). In multiple regression models, significant predictors of aMCR-T included lean body mass ([I]P[/I] = 0.008), percent fat mass ([I]P[/I] = 0.009), and SHBG ([I]P[/I] = 0.001). [B]Conclusions:[/B] Higher testosterone levels in older men receiving TE were associated with an age-related decrease in apparent testosterone metabolic clearance rates. Body composition and SHBG were significant predictors of aMCR-T. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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