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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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<blockquote data-quote="Cataceous" data-source="post: 167331" data-attributes="member: 38109"><p>Expand your thinking on the free T computation. Basically there are four variables: SHBG, albumin, free T and total T. If you know any three then you can compute the fourth. My assumptions lead to specifying the first three. If you accept these assumptions then it's ok to think of total T as a dependent variable, a function of the other three, and my other statements are a logical result. So which particular underlying assumption do you disagree with and why? Here they are:</p><p></p><p>• On average the exogenous testosterone taken in matches the amount metabolized and/or excreted.</p><p>• The metabolic clearance rate is linear in free testosterone, so the rate of loss is k * FT. See <a href="https://en.wikipedia.org/wiki/Law_of_mass_action" target="_blank">Law of Mass Action</a>.</p><p>• The underlying metabolism doesn't change, so the constant "k" does not change appreciably. This is the best avenue for criticism, but I see no reason to believe that my numbers are unique. And indeed, articles like <a href="https://www.glowm.com/section_view/heading/Production,+Clearance,+and+Measurement+of+Steroid+Hormones/item/277" target="_blank">this one</a> generally treat MCR as a fixed constant.</p><p></p><p>Your question about excreting bound testosterone is fair. But the binding proteins are used to prevent early excretion, and a couple facts show that loss via this route, if it exists, is negligible. First "In the healthy <a href="https://en.wikipedia.org/wiki/Kidney" target="_blank">kidney</a>, albumin's size and negative electric charge exclude it from excretion in the <a href="https://en.wikipedia.org/wiki/Glomerulus" target="_blank">glomerulus</a>."[<a href="https://en.wikipedia.org/wiki/Human_serum_albumin#Loss_via_kidneys" target="_blank">1</a>] And second, the half-life of SHBG is several days.[<a href="https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9285" target="_blank">2</a>] This must be contrasted with the half-life of free testosterone in serum, which is on the order of minutes. In other words, even if SHBG-bound testosterone were escaping, the rate of loss would be very low.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 167331, member: 38109"] Expand your thinking on the free T computation. Basically there are four variables: SHBG, albumin, free T and total T. If you know any three then you can compute the fourth. My assumptions lead to specifying the first three. If you accept these assumptions then it's ok to think of total T as a dependent variable, a function of the other three, and my other statements are a logical result. So which particular underlying assumption do you disagree with and why? Here they are: • On average the exogenous testosterone taken in matches the amount metabolized and/or excreted. • The metabolic clearance rate is linear in free testosterone, so the rate of loss is k * FT. See [URL='https://en.wikipedia.org/wiki/Law_of_mass_action']Law of Mass Action[/URL]. • The underlying metabolism doesn't change, so the constant "k" does not change appreciably. This is the best avenue for criticism, but I see no reason to believe that my numbers are unique. And indeed, articles like [URL='https://www.glowm.com/section_view/heading/Production,+Clearance,+and+Measurement+of+Steroid+Hormones/item/277']this one[/URL] generally treat MCR as a fixed constant. Your question about excreting bound testosterone is fair. But the binding proteins are used to prevent early excretion, and a couple facts show that loss via this route, if it exists, is negligible. First "In the healthy [URL='https://en.wikipedia.org/wiki/Kidney']kidney[/URL], albumin's size and negative electric charge exclude it from excretion in the [URL='https://en.wikipedia.org/wiki/Glomerulus']glomerulus[/URL]."[[URL='https://en.wikipedia.org/wiki/Human_serum_albumin#Loss_via_kidneys']1[/URL]] And second, the half-life of SHBG is several days.[[URL='https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9285']2[/URL]] This must be contrasted with the half-life of free testosterone in serum, which is on the order of minutes. In other words, even if SHBG-bound testosterone were escaping, the rate of loss would be very low. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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