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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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<blockquote data-quote="Cataceous" data-source="post: 166200" data-attributes="member: 38109"><p>Here are some ideas that have been floated:</p><p></p><p>• For a given level of free testosterone, lower SHBG leads to higher free estradiol; the low-SHBG guy naturally has a lower fT:fE2 ratio, and we know that trying to regulate E2 with aromatase inhibitors can be tricky.</p><p></p><p>• My assumption above about the stability of underlying testosterone metabolism could be incorrect. For me it's been stable over a period of five years, with SHBG varying from low 40s nMol/L to upper 20s. But if SHBG does affect this metabolism in a manner independent of free testosterone then it's possible low-SHBG guys could be relatively high excreters. Nonetheless, on steady-state TRT one still cannot excrete more or faster than what's being put in.</p><p></p><p>• There are SHBG receptors that rely on SHBG to deliver testosterone. Low SHBG could negatively affect this. So far I have not seen anyone flesh out the possible effects of this, nor discuss the relative importance of it compared to delivery of testosterone to androgen receptors.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 166200, member: 38109"] Here are some ideas that have been floated: • For a given level of free testosterone, lower SHBG leads to higher free estradiol; the low-SHBG guy naturally has a lower fT:fE2 ratio, and we know that trying to regulate E2 with aromatase inhibitors can be tricky. • My assumption above about the stability of underlying testosterone metabolism could be incorrect. For me it's been stable over a period of five years, with SHBG varying from low 40s nMol/L to upper 20s. But if SHBG does affect this metabolism in a manner independent of free testosterone then it's possible low-SHBG guys could be relatively high excreters. Nonetheless, on steady-state TRT one still cannot excrete more or faster than what's being put in. • There are SHBG receptors that rely on SHBG to deliver testosterone. Low SHBG could negatively affect this. So far I have not seen anyone flesh out the possible effects of this, nor discuss the relative importance of it compared to delivery of testosterone to androgen receptors. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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