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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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<blockquote data-quote="Cataceous" data-source="post: 166175" data-attributes="member: 38109"><p>The rate at which you absorb an injected ester like propionate determines serum testosterone. This rate is virtually independent of SHBG. End of story.</p><p></p><p>The myth that SHBG affects ester half-life has its roots in various things: If total testosterone is held constant then lower SHBG does mean higher free T. Consumption/excretion of testosterone is proportional to free T. Thus someone inferred that low-SHBG guys must be "peeing out" their testosterone faster than others, meaning a shorter effective half-life. Further "evidence" was found in those whose SHBG happened to drop quite a bit while on an unchanging dose of testosterone; they measured total testosterone and saw that it dropped as well.</p><p></p><p>But these observations are misinterpreted. First, those on TRT do not have fixed total testosterone. In fact it's free testosterone that is fairly fixed. Think of it this way: You're taking in a fixed amount of exogenous testosterone every week. At steady state you have to be using/excreting exactly the same amount every week. Otherwise you'd be building up or depleting testosterone in the body, which is not steady state. As noted, the rate of use and excretion of testosterone is proportional to free testosterone. The constant of proportionality is related to underlying metabolism, and probably changes slowly, if at all. Suppose your SHBG suddenly changed dramatically. What happens at the new steady state? You must still be excreting the same amount of testosterone each week. Thus free testosterone must be unchanged after the transition, and total testosterone adjusts to preserve this level of free T at the new SHBG.</p><p></p><p>This also explains the drop in total testosterone when SHBG falls while dose remains the same. Free testosterone initially wants to rise, but this "drains off" total testosterone until there's a new equilibrium with the same free T, but lower total testosterone. The Tru-T calculator can be used in reverse to find the new expected level of total testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 166175, member: 38109"] The rate at which you absorb an injected ester like propionate determines serum testosterone. This rate is virtually independent of SHBG. End of story. The myth that SHBG affects ester half-life has its roots in various things: If total testosterone is held constant then lower SHBG does mean higher free T. Consumption/excretion of testosterone is proportional to free T. Thus someone inferred that low-SHBG guys must be "peeing out" their testosterone faster than others, meaning a shorter effective half-life. Further "evidence" was found in those whose SHBG happened to drop quite a bit while on an unchanging dose of testosterone; they measured total testosterone and saw that it dropped as well. But these observations are misinterpreted. First, those on TRT do not have fixed total testosterone. In fact it's free testosterone that is fairly fixed. Think of it this way: You're taking in a fixed amount of exogenous testosterone every week. At steady state you have to be using/excreting exactly the same amount every week. Otherwise you'd be building up or depleting testosterone in the body, which is not steady state. As noted, the rate of use and excretion of testosterone is proportional to free testosterone. The constant of proportionality is related to underlying metabolism, and probably changes slowly, if at all. Suppose your SHBG suddenly changed dramatically. What happens at the new steady state? You must still be excreting the same amount of testosterone each week. Thus free testosterone must be unchanged after the transition, and total testosterone adjusts to preserve this level of free T at the new SHBG. This also explains the drop in total testosterone when SHBG falls while dose remains the same. Free testosterone initially wants to rise, but this "drains off" total testosterone until there's a new equilibrium with the same free T, but lower total testosterone. The Tru-T calculator can be used in reverse to find the new expected level of total testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who's currently on T propionate?
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