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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who Started TRT w/ "Normal" Levels @ What Age?
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<blockquote data-quote="aneuman" data-source="post: 219115" data-attributes="member: 43264"><p>These are some other labs:</p><p></p><p>Prolactin: <strong>6.1 mIU/mL</strong> (Reference Range: 2.0-18.0 ng/mL)</p><p></p><p>By the way, prolactin has been going down (<strong>9.2 in 2020, 7 in 2021, now 6.1</strong>)</p><p></p><p>ESTRADIOL,ULTRASENSITIVE, LC/MS: <strong> 31 pg/mL</strong> (Reference Range: < OR = 29 pg/mL)</p><p>DHEA SULFATE: <strong> 228 mcg/mL</strong> (Reference Range: 250-1100 ng/dL). Before that, my E2 level was around 27 pg/mL and Total T was 492 ng/dL (all natural, no interventions of any type) and I had the low libido and feeling like crap symptoms.</p><p></p><p>This progesterone test is an old result, before after the crash I had with HCG, when my TT levels were 309 (about 3 months ago, back in December)</p><p>17-HYDROXYPROGESTERONE: <strong>72 ng/dL</strong> (Reference Range: 37-129 ng/dL)</p><p></p><p>Curiously, even though Estradiol <strong>31 pg/mL</strong> is considered HIGH by Quest, it is equivalent to 3.1 ng/dL, which is less than <strong>5 ng/dL</strong>. See below:</p><p></p><p><strong>"</strong><em>In addition, a study by Ramasamy et al. in 2014 showed that libido was increased in men receiving TST when testosterone levels were >300 ng dl-1<strong> and estradiol levels were >5 ng/dl.</strong> Most compelling is the fact that in men with serum testosterone <300 ng dl-1, <strong>sexual drive was seen to be markedly higher when estradiol levels were >5 ng/dl.</strong> In addition, when patients with low testosterone were treated with letrozole, a potent aromatase inhibitor, libido was decreased, suggesting that complete elimination of estradiol and decreasing the T/E ratio too severely, adversely affects sexual desire in men</em>"</p><p></p><p><a href="http://Here%27s a link to the paper by Ramasamy" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/</a></p><p></p><p>Could it just be that men feel better when they have high T simply because high T also implies higher E2 (up to certain limits) due to aromatization and that it is the higher E2 (around 5-7 ng/dL maybe) what restores the libido, etc, and not necessarily T itself? It's very common it seems that anastrozole kills libido en many men on TRT, or so I've heard.</p><p></p><p>So it could be that my estradiol works better in the low 20pg/mL or that I need at least 50 ng/mL. Definitely I don't think I'd need T levels above 800 to solve these issues.</p><p></p><p>By the way, I've been taking Cialis 5 mg daily for years due to BPH (along with Alfuzosin at night) and I have the nagging feeling that Cialis has something to do with lack of penile sensation and libido, can't put my finger on it on why, but I've felt the correlation. It's known that Tadalafil lowers estradiol (E2). Any thoughts on that?</p><p></p><p>I'm very thankful to all the people that has responded. You guys are making a tough period easier and less stressful. Your suggestions and comments are all welcome and well taken.</p><p></p><p>Thanks.</p></blockquote><p></p>
[QUOTE="aneuman, post: 219115, member: 43264"] These are some other labs: Prolactin: [B]6.1 mIU/mL[/B] (Reference Range: 2.0-18.0 ng/mL) By the way, prolactin has been going down ([B]9.2 in 2020, 7 in 2021, now 6.1[/B]) ESTRADIOL,ULTRASENSITIVE, LC/MS: [B] 31 pg/mL[/B] (Reference Range: < OR = 29 pg/mL) DHEA SULFATE: [B] 228 mcg/mL[/B] (Reference Range: 250-1100 ng/dL). Before that, my E2 level was around 27 pg/mL and Total T was 492 ng/dL (all natural, no interventions of any type) and I had the low libido and feeling like crap symptoms. This progesterone test is an old result, before after the crash I had with HCG, when my TT levels were 309 (about 3 months ago, back in December) 17-HYDROXYPROGESTERONE: [B]72 ng/dL[/B] (Reference Range: 37-129 ng/dL) Curiously, even though Estradiol [B]31 pg/mL[/B] is considered HIGH by Quest, it is equivalent to 3.1 ng/dL, which is less than [B]5 ng/dL[/B]. See below: [B]"[/B][I]In addition, a study by Ramasamy et al. in 2014 showed that libido was increased in men receiving TST when testosterone levels were >300 ng dl-1[B] and estradiol levels were >5 ng/dl.[/B] Most compelling is the fact that in men with serum testosterone <300 ng dl-1, [B]sexual drive was seen to be markedly higher when estradiol levels were >5 ng/dl.[/B] In addition, when patients with low testosterone were treated with letrozole, a potent aromatase inhibitor, libido was decreased, suggesting that complete elimination of estradiol and decreasing the T/E ratio too severely, adversely affects sexual desire in men[/I]" [URL='http://Here%27s a link to the paper by Ramasamy']https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/[/URL] Could it just be that men feel better when they have high T simply because high T also implies higher E2 (up to certain limits) due to aromatization and that it is the higher E2 (around 5-7 ng/dL maybe) what restores the libido, etc, and not necessarily T itself? It's very common it seems that anastrozole kills libido en many men on TRT, or so I've heard. So it could be that my estradiol works better in the low 20pg/mL or that I need at least 50 ng/mL. Definitely I don't think I'd need T levels above 800 to solve these issues. By the way, I've been taking Cialis 5 mg daily for years due to BPH (along with Alfuzosin at night) and I have the nagging feeling that Cialis has something to do with lack of penile sensation and libido, can't put my finger on it on why, but I've felt the correlation. It's known that Tadalafil lowers estradiol (E2). Any thoughts on that? I'm very thankful to all the people that has responded. You guys are making a tough period easier and less stressful. Your suggestions and comments are all welcome and well taken. Thanks. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who Started TRT w/ "Normal" Levels @ What Age?
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