There are still relatively few guys on enclomiphene monotherapy, making it difficult to judge. My expectation is that results with enclomiphene should on average be somewhat better than with clomiphene. The reasoning is that clomiphene is essentially enclomiphene plus estrogen (zuclomiphene). While some guys need more estrogenic activity, I expect that most do not. Of course without more concrete information it's easy to put forth a completely different hypothesis. For example: Enclomiphene is such a strong estrogen blocker that it's actually useful to temper it with zuclomiphene.
I find it bothersome that there's still a lot to be understood about these drugs. Even within a single organ there appear to be contradictory effects. Enclomiphene doesn't affect SHBG, but clomiphene typically raises SHBG substantially, presumably due to the estrogenic effects of zuclomiphene in the liver. On the other hand, both clomiphene and enclomiphene reduce IGF-1, which is also produced primarily in the liver.
