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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who feels better on e5d or e7d compared.to more frequent shots?
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<blockquote data-quote="madman" data-source="post: 209134" data-attributes="member: 13851"><p>When using the most commonly prescribed T esters (cypionate/enanthate) it will take 4-6 weeks for blood levels to stabilize due to the half-life.</p><p></p><p>Blood work is done at 6 weeks and we test at the true trough.</p><p></p><p>Read over the thread: <a href="https://www.excelmale.com/forum/threads/short-vs-long-esters.23282/#post-199794" target="_blank">Short vs long esters</a></p><p></p><p><strong><em>*Following the initiation of testosterone therapy, <u>serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD</u></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*<u>As such, patients should be counseled that symptom response will not be immediate</u>. Expectations for treatment response should be established with each patient. <u>Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer</u>. Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6-months. 77 </em></strong>In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes</p><p></p><p><strong><em>*Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic/structural/metabolic benefit). However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the <u>clinical response tends to be more reflective of normalized levels of serum testosterone</u></em></strong></p><p></p><p></p><p></p><p></p><p>Look over:</p><p></p><p><strong>post #64/68/77</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/thinking-about-starting-trt.23894/page-4[/URL]</p><p></p><p></p><p><strong>post #77</strong> sums it up nicely</p><p></p><p>Whether one is starting trt or tweaking a protocol (increasing dose) anyone who has an understanding of how esterified exogenous T works should very well know that it is very common for one to experience what we call a honeymoon period during the weeks leading up until blood levels have stabilized as dopamine/androgen levels are increasing (AR receptors lighting up) and many tend to experience an almost euphoric like feeling let alone strong increases in libido/erections and overall well-being.....unfortunately this is temporary and short-lived as the body will eventually adapt and things tend to level off.....gauging how you truly feel during this transition is a grave mistake.</p><p></p><p>Even when tweaking a protocol (decreasing dose) it is very common for one to experience ups/downs let alone be in for a bumpy ride during the weeks leading up until blood levels have stabilized (4-6 weeks) only to end up feeling much better 2-3 months in on such protocol.</p><p></p><p>Once blood levels have stabilized (4-6 weeks) and the new set point is reached the next couple of months is where the rubber meets the road.</p><p></p><p>This is when one should truly gauge how they feel overall regarding relief/improvement of low-T symptoms let alone claiming whether such protocol is a success or failure.</p><p></p><p>Unfortunately, everyone is in for that quick fix!</p><p></p><p>Top it all off that many take drastic measures when tweaking a protocol (increasing/decreasing dose too much) of the hop and again it is common for many to experience ups/downs during the following weeks leading up until blood levels have stabilized (4-6 weeks)</p><p></p><p>The new protocol needs to be given a fighting chance as we need to allow the body time to fully adapt to the new set point which was reached once blood levels have stabilized (first 4-6 weeks).</p><p></p><p>Do not even get me started on the ones that are jacked up on T from the get-go (200 mg T/week) that has them feeling stellar for the first 6 weeks only to be let down 2-3 months in because trough FT levels are way too high leaving them feeling horrible.</p><p></p><p>If they had any sense in their heads let alone understood how esterified exogenous T works then they would be prepared for the fact 12 weeks is needed to truly gauge the effectiveness of a protocol and whether it was a success or failure.</p><p></p><p>The body will eventually adapt to the new setpoint and this will become the new norm.</p><p></p><p>Every time you decide to switch things up (increase/decrease dose T) the body will need time to <u>fully adapt once the new setpoint is reached</u>.</p><p></p><p>Although effects on quality of life become evident within 3–6 weeks the maximum benefits take longer.</p></blockquote><p></p>
[QUOTE="madman, post: 209134, member: 13851"] When using the most commonly prescribed T esters (cypionate/enanthate) it will take 4-6 weeks for blood levels to stabilize due to the half-life. Blood work is done at 6 weeks and we test at the true trough. Read over the thread: [URL='https://www.excelmale.com/forum/threads/short-vs-long-esters.23282/#post-199794']Short vs long esters[/URL] [B][I]*Following the initiation of testosterone therapy, [U]serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD[/U] *[U]As such, patients should be counseled that symptom response will not be immediate[/U]. Expectations for treatment response should be established with each patient. [U]Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer[/U]. Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6-months. 77 [/I][/B]In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes [B][I]*Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy *For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic/structural/metabolic benefit). However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the [U]clinical response tends to be more reflective of normalized levels of serum testosterone[/U][/I][/B] Look over: [B]post #64/68/77[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/thinking-about-starting-trt.23894/page-4[/URL] [B]post #77[/B] sums it up nicely Whether one is starting trt or tweaking a protocol (increasing dose) anyone who has an understanding of how esterified exogenous T works should very well know that it is very common for one to experience what we call a honeymoon period during the weeks leading up until blood levels have stabilized as dopamine/androgen levels are increasing (AR receptors lighting up) and many tend to experience an almost euphoric like feeling let alone strong increases in libido/erections and overall well-being.....unfortunately this is temporary and short-lived as the body will eventually adapt and things tend to level off.....gauging how you truly feel during this transition is a grave mistake. Even when tweaking a protocol (decreasing dose) it is very common for one to experience ups/downs let alone be in for a bumpy ride during the weeks leading up until blood levels have stabilized (4-6 weeks) only to end up feeling much better 2-3 months in on such protocol. Once blood levels have stabilized (4-6 weeks) and the new set point is reached the next couple of months is where the rubber meets the road. This is when one should truly gauge how they feel overall regarding relief/improvement of low-T symptoms let alone claiming whether such protocol is a success or failure. Unfortunately, everyone is in for that quick fix! Top it all off that many take drastic measures when tweaking a protocol (increasing/decreasing dose too much) of the hop and again it is common for many to experience ups/downs during the following weeks leading up until blood levels have stabilized (4-6 weeks) The new protocol needs to be given a fighting chance as we need to allow the body time to fully adapt to the new set point which was reached once blood levels have stabilized (first 4-6 weeks). Do not even get me started on the ones that are jacked up on T from the get-go (200 mg T/week) that has them feeling stellar for the first 6 weeks only to be let down 2-3 months in because trough FT levels are way too high leaving them feeling horrible. If they had any sense in their heads let alone understood how esterified exogenous T works then they would be prepared for the fact 12 weeks is needed to truly gauge the effectiveness of a protocol and whether it was a success or failure. The body will eventually adapt to the new setpoint and this will become the new norm. Every time you decide to switch things up (increase/decrease dose T) the body will need time to [U]fully adapt once the new setpoint is reached[/U]. Although effects on quality of life become evident within 3–6 weeks the maximum benefits take longer. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Who feels better on e5d or e7d compared.to more frequent shots?
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