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It seems to be it is coming down to more of a ratio of T/E, which many have pointed out here before. Hopefully this thread will help new members or new to TRT not to get so focused on a E2 number. I know a lot of other sites state you need E2 closest to 20 or need a T/E ratio 50:1 and so on. I think this gets most people confused or hooked up on a number. I know myself have change my attitude on E2, this site is filled with tons of info and real experiences.