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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
What's Coming? Accurate measurement of total and free testosterone levels for the diagnosis of androgen disorders
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<blockquote data-quote="madman" data-source="post: 228758" data-attributes="member: 13851"><p><strong>RESEARCH AGENDA</strong></p><p><strong></strong></p><p><strong><em>*The availability of high-quality testosterone assays, especially LC-MS/MA assays, has remained constrained in most countries outside the US. Increasing access to high-quality, affordable assays; harmonization of assays across laboratories; and generation of reference ranges that can be applied to people of various racial and ethnic groups in different regions of the world is necessary to improve the quality of care and health outcomes for men across the globe</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*The dynamics of the binding of testosterone to SHBG, human serum albumin, orosomucoid, and corticosteroid-binding globulin and the roles of these binding proteins in regulating testosterone's bioavailability to the tissues remain incompletely understood and need further investigation </em></strong></p><p><strong><em></em></strong></p><p><em><strong>*The lack of standardization of the equilibrium dialysis method for the measurement of free testosterone has been a barrier to the generation of rigorously derived harmonized reference ranges for free testosterone levels in men. The reference ranges for free testosterone levels measured using a standardized equilibrium dialysis method that can be applied across laboratories is an unmet need</strong></em></p><p></p><p><strong><em>*The risk of misdiagnosis of testosterone deficiency is high when testosterone levels are close to the lower limit of the normal range. Validation of additional biomarkers of testosterone deficiency is needed to improve the diagnostic accuracy, especially in men with testosterone levels that are only slightly below or slightly above the lower limit of the normal range</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 228758, member: 13851"] [B]RESEARCH AGENDA [I]*The availability of high-quality testosterone assays, especially LC-MS/MA assays, has remained constrained in most countries outside the US. Increasing access to high-quality, affordable assays; harmonization of assays across laboratories; and generation of reference ranges that can be applied to people of various racial and ethnic groups in different regions of the world is necessary to improve the quality of care and health outcomes for men across the globe *The dynamics of the binding of testosterone to SHBG, human serum albumin, orosomucoid, and corticosteroid-binding globulin and the roles of these binding proteins in regulating testosterone's bioavailability to the tissues remain incompletely understood and need further investigation [/I][/B] [I][B]*The lack of standardization of the equilibrium dialysis method for the measurement of free testosterone has been a barrier to the generation of rigorously derived harmonized reference ranges for free testosterone levels in men. The reference ranges for free testosterone levels measured using a standardized equilibrium dialysis method that can be applied across laboratories is an unmet need[/B][/I] [B][I]*The risk of misdiagnosis of testosterone deficiency is high when testosterone levels are close to the lower limit of the normal range. Validation of additional biomarkers of testosterone deficiency is needed to improve the diagnostic accuracy, especially in men with testosterone levels that are only slightly below or slightly above the lower limit of the normal range[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
What's Coming? Accurate measurement of total and free testosterone levels for the diagnosis of androgen disorders
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