The overly referenced and misused study that Life Extension and others used to scare men about estradiol had several flaws:
1- Men with heart disease with average testosterone os 320 ng/dL were included
2- The old estradiol test was used so E2 was overestimated.
We know that testosterone converts to estradiol, so more testosterone will convert to more estradiol. To expect that a man with 1000 ng/dL total T should have the estradiol of a old man with heart disease with low T is just crazy.
Until someone does a study on healthy men with testosterone over 500 ng/dL and using the right test I will not drink the kool aid that most men online have.
Circulating estradiol and mortality in men with systolic chronic heart failure.
Article: Elevated Estradiol During Testosterone Replacement : To Treat or Not To Treat?
