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The overly referenced and misused study that Life Extension and others used to scare men about estradiol had several flaws:

1- Men with heart disease with average testosterone os 320 ng/dL were included

2- The old estradiol test was used so E2 was overestimated.

We know that testosterone converts to estradiol, so more testosterone will convert to more estradiol. To expect that a man with 1000 ng/dL total T should have the estradiol of a old man with heart disease with low T is just crazy.

Until someone does a study on healthy men with testosterone over 500 ng/dL and using the right test I will not drink the kool aid that most men online have.

Circulating estradiol and mortality in men with systolic chronic heart failure.

Article: Elevated Estradiol During Testosterone Replacement : To Treat or Not To Treat?

<blockquote data-quote="Nelson Vergel" data-source="post: 45706" data-attributes="member: 3">The overly referenced and misused study&nbsp; that Life Extension and others used to scare men about estradiol had several flaws:1- Men with&nbsp; heart disease with average testosterone os 320 ng/dL were included2- The old estradiol test was used so E2 was overestimated.We know that testosterone converts to estradiol, so more testosterone will convert to more&nbsp; estradiol. To expect that a man with 1000 ng/dL total T should have the estradiol of a old man with heart disease with low T is just crazy.Until someone does a study on healthy men with testosterone over 500 ng/dL and using the right test I will not drink the kool aid that most men online have.<a href="http://www.ncbi.nlm.nih.gov/pubmed/19436016" target="_blank">Circulating estradiol and mortality in men with systolic chronic heart failure.</a>A<a href="https://www.excelmale.com/forum/showthread.php?4206-Article-Elevated-Estradiol-During-Testosterone-Replacement-To-Treat-or-Not-To-Treat" target="_blank">rticle: Elevated Estradiol During Testosterone Replacement : To Treat or Not To Treat?</a></blockquote>

[QUOTE="Nelson Vergel, post: 45706, member: 3"] The overly referenced and misused study that Life Extension and others used to scare men about estradiol had several flaws: 1- Men with heart disease with average testosterone os 320 ng/dL were included 2- The old estradiol test was used so E2 was overestimated. We know that testosterone converts to estradiol, so more testosterone will convert to more estradiol. To expect that a man with 1000 ng/dL total T should have the estradiol of a old man with heart disease with low T is just crazy. Until someone does a study on healthy men with testosterone over 500 ng/dL and using the right test I will not drink the kool aid that most men online have. [B][URL="http://www.ncbi.nlm.nih.gov/pubmed/19436016"]Circulating estradiol and mortality in men with systolic chronic heart failure.[/URL][/B] [B]A[URL="https://www.excelmale.com/forum/showthread.php?4206-Article-Elevated-Estradiol-During-Testosterone-Replacement-To-Treat-or-Not-To-Treat"]rticle: Elevated Estradiol During Testosterone Replacement : To Treat or Not To Treat?[/URL][/B] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038