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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What kind of levels to expect from 100mg weekly
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<blockquote data-quote="Cataceous" data-source="post: 189989" data-attributes="member: 38109"><p>Just as an academic exercise it's interesting to make a rough prediction of the average serum testosterone levels an average young man would achieve with 100 mg testosterone cypionate per week. Here are the assumptions:</p><ul> <li data-xf-list-type="ul">Average natural testosterone production: 6-7 mg</li> <li data-xf-list-type="ul"><span style="font-size: 14px">Average peak testosterone 600-700 ng/dL</span></li> <li data-xf-list-type="ul"><span style="font-size: 14px">Diurnal variation off of peak: 40%</span></li> <li data-xf-list-type="ul"><span style="font-size: 14px">No change in albumin or SHBG</span></li> </ul><p><span style="font-size: 14px">We'll just use 6.5 mg natural T production resulting in 650 ng/dL TT. So weekly natural production is 45.5 mg T, which is the amount contained in 65 mg T cypionate. We convert from peak to average serum testosterone by multiplying by 80%: 520 ng/dL. With unchanging albumin and SHBG we'll assume that total testosterone is linear with dose. Therefore:</span></p><p><span style="font-size: 14px"></span></p><p><span style="font-size: 14px">TT(avg-100mg/w) = 520 ng/dL * 100 mg TC / 65 mg TC = <strong>800 ng/dL</strong></span></p><p><span style="font-size: 14px"></span></p><p><span style="font-size: 14px">This is the predicted <em>average</em> serum level, meaning it's what would be measured if the guy were injecting frequently, e.g. daily and maybe even EOD. But suppose he starts out with injections once a week and has typical absorption for cypionate, meaning a 5-day half-life. Then he measures a trough level of about <strong>450 ng/dL</strong>. We see this kind of thing all the time. Guys measure a lowish trough like this and want to greatly increase the dose. But the post-injection peak in testosterone is ignored. In this example it is more like 1,150 ng/dL.</span></p><p><span style="font-size: 14px"></span></p><p><span style="font-size: 14px">It wouldn't be uncommon in a case like this for the dose to be increased by 50% to raise the trough measurement to healthy-young-man levels of 600-700 ng/dL. Unseen is that the average serum testosterone jumps to 1,200 ng/dL and the peak rises to over 1,700. Then people are surprised when all the side effects kick in: HCT, E2 issues, DHT issues, etc.</span></p></blockquote><p></p>
[QUOTE="Cataceous, post: 189989, member: 38109"] Just as an academic exercise it's interesting to make a rough prediction of the average serum testosterone levels an average young man would achieve with 100 mg testosterone cypionate per week. Here are the assumptions: [LIST] [*]Average natural testosterone production: 6-7 mg [*][SIZE=14px]Average peak testosterone 600-700 ng/dL[/SIZE] [*][SIZE=14px]Diurnal variation off of peak: 40%[/SIZE] [*][SIZE=14px]No change in albumin or SHBG[/SIZE] [/LIST] [SIZE=14px]We'll just use 6.5 mg natural T production resulting in 650 ng/dL TT. So weekly natural production is 45.5 mg T, which is the amount contained in 65 mg T cypionate. We convert from peak to average serum testosterone by multiplying by 80%: 520 ng/dL. With unchanging albumin and SHBG we'll assume that total testosterone is linear with dose. Therefore: TT(avg-100mg/w) = 520 ng/dL * 100 mg TC / 65 mg TC = [B]800 ng/dL[/B] This is the predicted [I]average[/I] serum level, meaning it's what would be measured if the guy were injecting frequently, e.g. daily and maybe even EOD. But suppose he starts out with injections once a week and has typical absorption for cypionate, meaning a 5-day half-life. Then he measures a trough level of about [B]450 ng/dL[/B]. We see this kind of thing all the time. Guys measure a lowish trough like this and want to greatly increase the dose. But the post-injection peak in testosterone is ignored. In this example it is more like 1,150 ng/dL. It wouldn't be uncommon in a case like this for the dose to be increased by 50% to raise the trough measurement to healthy-young-man levels of 600-700 ng/dL. Unseen is that the average serum testosterone jumps to 1,200 ng/dL and the peak rises to over 1,700. Then people are surprised when all the side effects kick in: HCT, E2 issues, DHT issues, etc.[/SIZE] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What kind of levels to expect from 100mg weekly
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