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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What kind of levels to expect from 100mg weekly
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<blockquote data-quote="madman" data-source="post: 189917" data-attributes="member: 13851"><p>No one can say for sure as many factors come into play (dose T/SHBG level/ sensitivity of the AR, polymorphism of the AR and CAG repeat length (long/short), body weight, injection frequency).</p><p></p><p>Although TT is important to know I would be much more concerned with what FT level is achieved on such protocol (dose of T/injection frequency).</p><p></p><p>Too many get caught up on where TT levels will end up when FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>Keep in mind that when first starting trt not only will your hpta be shutting down (within 2-6 weeks) but your testosterone levels will be rising and in flux during the weeks leading up until blood levels stabilize (4-6 weeks).</p><p></p><p>During this critical time, there is a lot going on, and depending on the individual many will experience what we call the honeymoon period where one can feel euphoric with an increase in libido due to androgen levels rising/increase in dopamine and this is usually temporary and short-lived as the body will eventually adapt.</p><p></p><p>It is also common for many to experience bumps (ups/downs) along the way as T levels are in flux.</p><p></p><p>Many end up making the mistake of gauging how they feel during this time which can be very misleading as blood levels will not stabilize until 4-6 weeks in and even then once levels have stabilized it can take 2-3 months for the body to fully adapt to those new levels and this is the critical time period when one should truly gauge how they feel regarding relief/improvement of low-t symptoms and overall well-being.</p><p></p><p>Patience is key.</p><p></p><p>Blood work should be done at 6 weeks to not only see where said protocol (dose T/injection frequency) puts your TT/FT/e2 levels but also to make sure blood markers remain healthy as we want to avoid/minimize any potential side-effects long-term.</p><p></p><p>Blood work should be done at trough (lowest point) as we want to know where T levels sit as too low or too high could negate the beneficial effects of having healthy FT levels.</p><p></p><p>Seeing as you were started on once-weekly injections (100 mg/week) then if you are injecting Monday morning at 9 am then blood work would be done the following Monday morning before your 9 am injection as this would be your TRUE TROUGH (lowest point) blood levels.</p><p></p><p>When injecting larger doses of T once weekly levels will start rising within 2 hrs post-injection and peak 8-12 hrs as they will stay elevated during the first few days and decline to much lower levels (true trough) come weeks end.</p><p></p><p>The main downfall of injecting larger doses of T once weekly is that there can be a large difference in peak--->trough and blood levels will not be as stable throughout the week which in many cases can have a negative impact on energy/mood/libido/erectile function/recovery and overall well-being.</p><p></p><p>You would most likely do much better splitting the 100 mg/week dose into twice-weekly injections (50 mg every 3.5 days) and depending on SHBG may even need to inject more frequently as in EOD or daily as this will have a big impact on not only clipping the peak--->trough but result in much more stable levels throughout the week.</p><p></p><p>Stick to your protocol for the next 6 weeks then get blood work done and depending on labs and where your levels sit you may very well need a dose adjustment but this comes down to where your <span style="color: rgb(184, 49, 47)">TT/FT levels sit/<u>symptom relief (mind you 6 weeks is far too early to truly gauge this</u>)</span> if levels truly are still too low and you feel horrible at the 6-week mark than a dose adjustment will be needed let alone injection frequency may be tweaked.</p></blockquote><p></p>
[QUOTE="madman, post: 189917, member: 13851"] No one can say for sure as many factors come into play (dose T/SHBG level/ sensitivity of the AR, polymorphism of the AR and CAG repeat length (long/short), body weight, injection frequency). Although TT is important to know I would be much more concerned with what FT level is achieved on such protocol (dose of T/injection frequency). Too many get caught up on where TT levels will end up when FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. Keep in mind that when first starting trt not only will your hpta be shutting down (within 2-6 weeks) but your testosterone levels will be rising and in flux during the weeks leading up until blood levels stabilize (4-6 weeks). During this critical time, there is a lot going on, and depending on the individual many will experience what we call the honeymoon period where one can feel euphoric with an increase in libido due to androgen levels rising/increase in dopamine and this is usually temporary and short-lived as the body will eventually adapt. It is also common for many to experience bumps (ups/downs) along the way as T levels are in flux. Many end up making the mistake of gauging how they feel during this time which can be very misleading as blood levels will not stabilize until 4-6 weeks in and even then once levels have stabilized it can take 2-3 months for the body to fully adapt to those new levels and this is the critical time period when one should truly gauge how they feel regarding relief/improvement of low-t symptoms and overall well-being. Patience is key. Blood work should be done at 6 weeks to not only see where said protocol (dose T/injection frequency) puts your TT/FT/e2 levels but also to make sure blood markers remain healthy as we want to avoid/minimize any potential side-effects long-term. Blood work should be done at trough (lowest point) as we want to know where T levels sit as too low or too high could negate the beneficial effects of having healthy FT levels. Seeing as you were started on once-weekly injections (100 mg/week) then if you are injecting Monday morning at 9 am then blood work would be done the following Monday morning before your 9 am injection as this would be your TRUE TROUGH (lowest point) blood levels. When injecting larger doses of T once weekly levels will start rising within 2 hrs post-injection and peak 8-12 hrs as they will stay elevated during the first few days and decline to much lower levels (true trough) come weeks end. The main downfall of injecting larger doses of T once weekly is that there can be a large difference in peak--->trough and blood levels will not be as stable throughout the week which in many cases can have a negative impact on energy/mood/libido/erectile function/recovery and overall well-being. You would most likely do much better splitting the 100 mg/week dose into twice-weekly injections (50 mg every 3.5 days) and depending on SHBG may even need to inject more frequently as in EOD or daily as this will have a big impact on not only clipping the peak--->trough but result in much more stable levels throughout the week. Stick to your protocol for the next 6 weeks then get blood work done and depending on labs and where your levels sit you may very well need a dose adjustment but this comes down to where your [COLOR=rgb(184, 49, 47)]TT/FT levels sit/[U]symptom relief (mind you 6 weeks is far too early to truly gauge this[/U])[/COLOR] if levels truly are still too low and you feel horrible at the 6-week mark than a dose adjustment will be needed let alone injection frequency may be tweaked. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What kind of levels to expect from 100mg weekly
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