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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the reason low shbg needs ED injections?
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<blockquote data-quote="Gus80" data-source="post: 246750" data-attributes="member: 45069"><p>Just to put my question about using propionate in place of larger esters in context. I have an mthfr mutation and I've been researching for a few years about the relationship of this mutation with other altered genes like Comt and Maoa. According to studies by Dr Ben Lynch, when these genes are slow they cause problems in the elimination of dopamine, serotonin and estrogen. I've had some symptoms of serotonin syndrome using marijuana and pictures similar to psychosis using Ritalin or even caffeine in high doses. I have only mthfr test but symptoms of Slow Comt and Slow Maoa.</p><p></p><p>Several articles claim that estrogen increases serotonin. My hypothesis is that by slowly metabolizing testosterone and estrogen, those who have slow comt/maoa will have worse well being with higher doses of testosterone/e2.</p><p></p><p>Fast metabolizers, Fast Comt/Maoa, are the ones who benefit the most from high doses of testosterone/estrogen. These are the ones who feel a clear decrease in anxiety and depression when starting TRT.</p><p></p><p>Thinking about this slowness in metabolizing estrogen and since propionate has a short half-life, would there be any hypothetical benefit in these cases?</p></blockquote><p></p>
[QUOTE="Gus80, post: 246750, member: 45069"] Just to put my question about using propionate in place of larger esters in context. I have an mthfr mutation and I've been researching for a few years about the relationship of this mutation with other altered genes like Comt and Maoa. According to studies by Dr Ben Lynch, when these genes are slow they cause problems in the elimination of dopamine, serotonin and estrogen. I've had some symptoms of serotonin syndrome using marijuana and pictures similar to psychosis using Ritalin or even caffeine in high doses. I have only mthfr test but symptoms of Slow Comt and Slow Maoa. Several articles claim that estrogen increases serotonin. My hypothesis is that by slowly metabolizing testosterone and estrogen, those who have slow comt/maoa will have worse well being with higher doses of testosterone/e2. Fast metabolizers, Fast Comt/Maoa, are the ones who benefit the most from high doses of testosterone/estrogen. These are the ones who feel a clear decrease in anxiety and depression when starting TRT. Thinking about this slowness in metabolizing estrogen and since propionate has a short half-life, would there be any hypothetical benefit in these cases? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the reason low shbg needs ED injections?
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