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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the reason low shbg needs ED injections?
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<blockquote data-quote="Cataceous" data-source="post: 246741" data-attributes="member: 38109"><p>I've added a note to that post explaining that it may be using a flawed assumption. Nonetheless, low SHBG may be problematic, even if the reasons why are more complicated than a shift in the balance of free hormones. If low SHBG decreases androgenic activity relative to estrogenic activity then it is possible that nandrolone could push things in the right direction in some tissues. However, if the idea has merit then it would seem to make more sense to use a non-aromatizing steroid that has an androgenic/anabolic ratio closer to that of testosterone. DHT?</p><p></p><p>Taking low SHBG to the extreme, there's this <a href="https://academic.oup.com/jcem/article/99/9/E1798/2537696" target="_blank">interesting case study</a> in which male and female siblings had undetectable SHBG, and yet "... reported only mild symptoms, which could, however, not be directly related to the SHBG deficiency. Surprisingly, the absence of SHBG and the low sex hormone concentrations did not interfere with male gonadal differentiation or pubertal development and reproductive function of the gonads in both the male and the female."</p><p></p><p>The male still had some issues: "Despite normal free T levels, the patient had multiple signs that could be related to a decreased T availability: low libido, decreased spontaneous morning erections, fatigue, muscular weakness, decreased shaving frequency (once per 4 d), inability to concentrate, sleep disturbance, and depressed mood."</p></blockquote><p></p>
[QUOTE="Cataceous, post: 246741, member: 38109"] I've added a note to that post explaining that it may be using a flawed assumption. Nonetheless, low SHBG may be problematic, even if the reasons why are more complicated than a shift in the balance of free hormones. If low SHBG decreases androgenic activity relative to estrogenic activity then it is possible that nandrolone could push things in the right direction in some tissues. However, if the idea has merit then it would seem to make more sense to use a non-aromatizing steroid that has an androgenic/anabolic ratio closer to that of testosterone. DHT? Taking low SHBG to the extreme, there's this [URL='https://academic.oup.com/jcem/article/99/9/E1798/2537696']interesting case study[/URL] in which male and female siblings had undetectable SHBG, and yet "... reported only mild symptoms, which could, however, not be directly related to the SHBG deficiency. Surprisingly, the absence of SHBG and the low sex hormone concentrations did not interfere with male gonadal differentiation or pubertal development and reproductive function of the gonads in both the male and the female." The male still had some issues: "Despite normal free T levels, the patient had multiple signs that could be related to a decreased T availability: low libido, decreased spontaneous morning erections, fatigue, muscular weakness, decreased shaving frequency (once per 4 d), inability to concentrate, sleep disturbance, and depressed mood." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the reason low shbg needs ED injections?
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