ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the lowest free testosterone blood level for low T symptoms?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 18415" data-attributes="member: 3"><p>Abstracts printed from AUA2015.org</p><hr /><p><strong>ASSOCIATION OF FREE TESTOSTERONE WITH HYPOGONADAL SYMPTOMS IN MEN WITH NEAR NORMAL TOTAL TESTOSTERONE LEVELS</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Authors:</strong> Nathan Wilken, Jason Scovell, Ranjith Ramasamy*, Dolores Lamb, Larry Lipshultz, Houston, TX</p><p><strong>Abstract: PD37-03</strong> </p><p><strong>Introduction and Objectives</strong> </p><p>To investigate the association between hypogonadal symptoms and calculated free testosterone levels in men with near normal total testosterone levels (250 – 350ng/dL). We also attempted to determine whether there exists a clear-cut discriminatory threshold of free testosterone below which hypogonadal symptoms become more prevalent. </p><p></p><p><strong>Methods</strong> </p><p>We retrospectively reviewed the charts of 3,167 men who presented to an outpatient men’s health clinic. Of these men, 231 men had a T value between 250 – 350 ng/dL with a chief complaint of “low testosterone”. Men using testosterone or other androgenic anabolic steroids (AAS) within 6 months of the time of the survey were excluded. We also excluded men who had presented with a primary diagnosis of infertility, Kleinfelter syndrome, or secondary hypogonadism after appropriate assessment of history and endocrine evaluation with gonadotropins. We evaluated hypogonadal symptoms using the Androgen deficiency in Aging Male (ADAM) questionnaire and quantitative ADAM questionnaire. Serum levels of total testosterone, sex-hormone binding globulin (SHBG) were collected on the same day that men completed their questionnaires. FT levels were calculated using the Vermeulen formula. We used locally weighted linear regression to identify threshold levels of FT below which the probability of a symptom increased above the background prevalence in the overall study population. We subsequently performed univariate (t test, chi-square) and multivariate analyses (ordinal logistic regression) to evaluate factors that predicted a low free testosterone level. </p><p></p><p><strong>Results</strong> </p><p>The mean age of the 231 men was 48.4 + 16.2 y, and the mean T level and FT levels were 292 + 36 ng/dL, and 6.7 + 1.26 ng/dL respectively. Significant associations between free testosterone levels and a number of androgen deficiency symptoms were seen at FT levels of 5.0 – 7.0 ng/dL, but multiple logistic regression analysis revealed confounding effects with age. Of the 10 hypogonadal symptoms, the probability of having psychological (decreased energy and sadness) and physical (decreased strength, falling asleep after dinner and deterioration of work performance) symptoms was associated with FT on a univariate analysis. However, on multivariable analysis, only younger age correlated positively with higher FT. </p><p></p><p><strong>Conclusions</strong> </p><p>Hypogonadal symptoms in men with near normal total testosterone levels can be associated with a free testosterone level. Symptom-specific free testosterone thresholds could not be defined, as age remains an important confounder.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 18415, member: 3"] Abstracts printed from AUA2015.org [HR][/HR][B]ASSOCIATION OF FREE TESTOSTERONE WITH HYPOGONADAL SYMPTOMS IN MEN WITH NEAR NORMAL TOTAL TESTOSTERONE LEVELS [/B] [B]Authors:[/B] Nathan Wilken, Jason Scovell, Ranjith Ramasamy*, Dolores Lamb, Larry Lipshultz, Houston, TX [B]Abstract: PD37-03[/B] [B]Introduction and Objectives[/B] To investigate the association between hypogonadal symptoms and calculated free testosterone levels in men with near normal total testosterone levels (250 – 350ng/dL). We also attempted to determine whether there exists a clear-cut discriminatory threshold of free testosterone below which hypogonadal symptoms become more prevalent. [B]Methods[/B] We retrospectively reviewed the charts of 3,167 men who presented to an outpatient men’s health clinic. Of these men, 231 men had a T value between 250 – 350 ng/dL with a chief complaint of “low testosterone”. Men using testosterone or other androgenic anabolic steroids (AAS) within 6 months of the time of the survey were excluded. We also excluded men who had presented with a primary diagnosis of infertility, Kleinfelter syndrome, or secondary hypogonadism after appropriate assessment of history and endocrine evaluation with gonadotropins. We evaluated hypogonadal symptoms using the Androgen deficiency in Aging Male (ADAM) questionnaire and quantitative ADAM questionnaire. Serum levels of total testosterone, sex-hormone binding globulin (SHBG) were collected on the same day that men completed their questionnaires. FT levels were calculated using the Vermeulen formula. We used locally weighted linear regression to identify threshold levels of FT below which the probability of a symptom increased above the background prevalence in the overall study population. We subsequently performed univariate (t test, chi-square) and multivariate analyses (ordinal logistic regression) to evaluate factors that predicted a low free testosterone level. [B]Results[/B] The mean age of the 231 men was 48.4 + 16.2 y, and the mean T level and FT levels were 292 + 36 ng/dL, and 6.7 + 1.26 ng/dL respectively. Significant associations between free testosterone levels and a number of androgen deficiency symptoms were seen at FT levels of 5.0 – 7.0 ng/dL, but multiple logistic regression analysis revealed confounding effects with age. Of the 10 hypogonadal symptoms, the probability of having psychological (decreased energy and sadness) and physical (decreased strength, falling asleep after dinner and deterioration of work performance) symptoms was associated with FT on a univariate analysis. However, on multivariable analysis, only younger age correlated positively with higher FT. [B]Conclusions[/B] Hypogonadal symptoms in men with near normal total testosterone levels can be associated with a free testosterone level. Symptom-specific free testosterone thresholds could not be defined, as age remains an important confounder. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the lowest free testosterone blood level for low T symptoms?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top