Yes and yes.
Over close to 2 years, I have gone through repeated dosage reductions and have gone below what seems the minimum effective dose for me.
I have been through high HCT/HGB and E2, and slightly elevated E2 is an ongoing problem that I have to manage with micro dosed AI.
It takes 2-3 months for me to fully adjust to reductions, and getting to that kind of end point can be an exercise in abject misery. At a few weeks out, the withdrawl is at its worst for me. Due to the half life of T cyp, the typical theoretical amount of time it takes to reach a new steady state is 4-6 weeks, but for me, the body itself takes much longer to adapt.
My lowest effective dose is 84mg/week dosed 24mg EOD. I do use HCG 200iu EOD and anastrozole 0.06mg EOD.