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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
What is the best dose of HCG? Dr Saya presents two case studies.
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 33298" data-attributes="member: 12687"><p>In the literal sense...this is true and indisputable.</p><p></p><p>But thinking of it from a different angle gives a different perspective. </p><p></p><p>Now LH indeed has a very short half-life AND is secreted in a pulsatile nature...BUT these pulses are many and frequent throughout the day (yes, more in the AM but throughout the day nonetheless) to the extent that at ANY time during the day an LH serum level is checked it will typically fall in the "normal" range of ~1.8mIU/mL - 8mIU/mL. Diurnal variation can be seen here: </p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681273/#__abstractid251532title" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681273/#__abstractid251532title</a></p><p></p><p>Contrast this with an HCG injection which has a much longer half-life, but is also only injected ONCE. Now if you compare this to a SINGLE LH PULSE it will be a drastically and distinctly different pattern. However, if you compare the pattern of the single HCG injection with the CUMULATIVE PATTERN of the MANY LH PULSES throughout the day...the pattern or "area under the curve" becomes much more similar (i.e. more constant and continual stimulation from both). Hope this makes sense.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 33298, member: 12687"] In the literal sense...this is true and indisputable. But thinking of it from a different angle gives a different perspective. Now LH indeed has a very short half-life AND is secreted in a pulsatile nature...BUT these pulses are many and frequent throughout the day (yes, more in the AM but throughout the day nonetheless) to the extent that at ANY time during the day an LH serum level is checked it will typically fall in the "normal" range of ~1.8mIU/mL - 8mIU/mL. Diurnal variation can be seen here: [url]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681273/#__abstractid251532title[/url] Contrast this with an HCG injection which has a much longer half-life, but is also only injected ONCE. Now if you compare this to a SINGLE LH PULSE it will be a drastically and distinctly different pattern. However, if you compare the pattern of the single HCG injection with the CUMULATIVE PATTERN of the MANY LH PULSES throughout the day...the pattern or "area under the curve" becomes much more similar (i.e. more constant and continual stimulation from both). Hope this makes sense. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
What is the best dose of HCG? Dr Saya presents two case studies.
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