ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
What has been your experience with progesterone?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 273456" data-attributes="member: 38109"><p>I was envisioning an experiment in which men would be given something like lilopristone, a PR antagonist, to see if anything bad happens. But you really need something that irreversibly binds to progesterone itself and effectively deactivates it. Then one would also be testing whether progesterone's opposition to estradiol is important.</p><p></p><p>I wouldn't be so quick to dismiss the importance of allopregnanolone. Wiki cites <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898141/" target="_blank">this reference</a> in saying that it is "prosexual". There is some discussion of human studies also.</p><p></p><p style="margin-left: 20px"><em>Our research has demonstrated that 3α,5α-THP facilitates social and sexual behavior of rodents, which evokes further increases in 3α,5α-THP in midbrain and hippocampus, brain areas involved in [social, cognitive, emotional and physical processes].</em></p><p></p><p>The drop in progesterone under TRT may be small in absolute terms, but losing half of the total seems significant. How is that unlikely to have biological consequences? Try losing half of your testosterone or estradiol. I also see that the lead author of the study received some perks from Bayer, which could be an incentive to downplay the issue.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 273456, member: 38109"] I was envisioning an experiment in which men would be given something like lilopristone, a PR antagonist, to see if anything bad happens. But you really need something that irreversibly binds to progesterone itself and effectively deactivates it. Then one would also be testing whether progesterone's opposition to estradiol is important. I wouldn't be so quick to dismiss the importance of allopregnanolone. Wiki cites [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898141/']this reference[/URL] in saying that it is "prosexual". There is some discussion of human studies also. [INDENT][I]Our research has demonstrated that 3α,5α-THP facilitates social and sexual behavior of rodents, which evokes further increases in 3α,5α-THP in midbrain and hippocampus, brain areas involved in [social, cognitive, emotional and physical processes].[/I][/INDENT] The drop in progesterone under TRT may be small in absolute terms, but losing half of the total seems significant. How is that unlikely to have biological consequences? Try losing half of your testosterone or estradiol. I also see that the lead author of the study received some perks from Bayer, which could be an incentive to downplay the issue. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
What has been your experience with progesterone?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top