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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
What has been your experience with progesterone?
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<blockquote data-quote="FunkOdyssey" data-source="post: 273438" data-attributes="member: 44064"><p>So this video was interesting, however I think he makes a mistake to attribute the hypersexual effects of various recreational drugs to their effects on allopregnanolone. All of those drugs increase dopamine signaling in the reward pathways and increase sexual desire directly with dopamine release. I also noticed a conspicuous absence of anyone confirming progesterone increased their sex drive in the 759 comments.</p><p></p><p>Not relevant to the topic but you may find it interesting how Leo met his end: <a href="https://www.thedailybeast.com/youtubes-penis-enlargement-grifter-leo-rex-suffers-bloody-death-in-thailand" target="_blank">YouTube’s ‘Penis Enlargement’ Grifter Suffers Bloody Death in Thailand</a></p><p></p><p>I did a little digging on progesterone today and found some interesting studies. <a href="https://shura.shu.ac.uk/30766/3/Kelly-TheEffectsOfLongTermTestosteroneTreatment%28VoR%29.pdf" target="_blank">One</a> followed men on TRT (Nebido, 1000mg E12W) for 12 years and charted a reduction in serum progesterone that was still within the normal range:</p><p></p><p>[ATTACH=full]40626[/ATTACH]</p><p></p><p>Their conclusions:</p><p></p><p></p><p>Another one that just came out used the latest and greatest test methods to quantify the levels of sex steroids in the CNS of men. This one is very interesting and may be worth its own thread. They found no detectable progesterone in male cerebrospinal fluid.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762557/[/URL]</p><p></p><p></p><p></p><p>This paper finds that dietary progesterone can contribute significantly to serum progesterone levels in male mice and propose that the same may be true in humans. Dairy products, eggs, and some meats are rich sources of dietary progesterone. It would be interesting to look at vegan men to see what their serum progesterone looks like without any dietary contributions. This raises the question for me: how much of your serum progesterone was supposed to be there and how much was just something you ate?</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345477/[/URL]</p><p></p><p></p><p></p><p>This study finds higher progesterone levels associated with metabolic syndrome in men, and cite prior research finding higher progesterone associated with prediabetes and T2DM in men.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536839/[/URL]</p><p></p><p>They speculate on some potential mechanisms:</p><p></p><p></p><p></p><p>Finally, the following study is a recent review of the effects of progesterone and ways in which it might be useful. They have a section on Progesterone in Men which is enlightening. The only function they list that would be relevant to men on TRT, unconcerned with fertility, are "interactions with the GABA-A receptor complex in the CNS, including sedative and anesthetic actions". We know the sedation well and it can be helpful in some cases.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322133/[/URL]</p><p></p><p></p><p></p><p>"Testicular and adrenal PROG has been regarded as a physiologically unimportant by-product of steroidogenesis." I think that sums up my current position. I remain open to new information though.</p><p></p><p>[ATTACH=full]40628[/ATTACH]</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 273438, member: 44064"] So this video was interesting, however I think he makes a mistake to attribute the hypersexual effects of various recreational drugs to their effects on allopregnanolone. All of those drugs increase dopamine signaling in the reward pathways and increase sexual desire directly with dopamine release. I also noticed a conspicuous absence of anyone confirming progesterone increased their sex drive in the 759 comments. Not relevant to the topic but you may find it interesting how Leo met his end: [URL='https://www.thedailybeast.com/youtubes-penis-enlargement-grifter-leo-rex-suffers-bloody-death-in-thailand']YouTube’s ‘Penis Enlargement’ Grifter Suffers Bloody Death in Thailand[/URL] I did a little digging on progesterone today and found some interesting studies. [URL='https://shura.shu.ac.uk/30766/3/Kelly-TheEffectsOfLongTermTestosteroneTreatment%28VoR%29.pdf']One[/URL] followed men on TRT (Nebido, 1000mg E12W) for 12 years and charted a reduction in serum progesterone that was still within the normal range: [ATTACH type="full" alt="prog.png"]40626[/ATTACH] Their conclusions: Another one that just came out used the latest and greatest test methods to quantify the levels of sex steroids in the CNS of men. This one is very interesting and may be worth its own thread. They found no detectable progesterone in male cerebrospinal fluid. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10762557/[/URL] This paper finds that dietary progesterone can contribute significantly to serum progesterone levels in male mice and propose that the same may be true in humans. Dairy products, eggs, and some meats are rich sources of dietary progesterone. It would be interesting to look at vegan men to see what their serum progesterone looks like without any dietary contributions. This raises the question for me: how much of your serum progesterone was supposed to be there and how much was just something you ate? [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345477/[/URL] This study finds higher progesterone levels associated with metabolic syndrome in men, and cite prior research finding higher progesterone associated with prediabetes and T2DM in men. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536839/[/URL] They speculate on some potential mechanisms: Finally, the following study is a recent review of the effects of progesterone and ways in which it might be useful. They have a section on Progesterone in Men which is enlightening. The only function they list that would be relevant to men on TRT, unconcerned with fertility, are "interactions with the GABA-A receptor complex in the CNS, including sedative and anesthetic actions". We know the sedation well and it can be helpful in some cases. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322133/[/URL] "Testicular and adrenal PROG has been regarded as a physiologically unimportant by-product of steroidogenesis." I think that sums up my current position. I remain open to new information though. [ATTACH type="full"]40628[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
What has been your experience with progesterone?
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