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General Peptide Use & Information
What Happens When Long Term Growth Hormone is Stopped
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<blockquote data-quote="Excel Male" data-source="post: 84" data-attributes="member: 1"><p>Study Looked at What Happens When Long Term Growth Hormone Replacement Therapy is Stopped</p><p></p><p><strong>Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency</strong></p><p></p><p></p><p>Department of Endocrinology, Sahlgrenska University Hospital, and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-41345 Göteborg, Sweden</p><p></p><p><strong>Abstract</strong></p><p></p><p><strong>Context:</strong> Adult GH deficiency (GHD) is associated with impaired quality of life (QoL) and increased cardiovascular risk. Continued long-term efficacy in terms of QoL and cardiovascular risk factors has been indicated in open surveillance studies.</p><p></p><p><strong>Objectives:</strong> The aim was to study the impact of discontinuation of long-term GH replacement on QoL, body composition, and metabolism.</p><p></p><p><strong>Design and Setting:</strong> We conducted a randomized, double-blind, placebo-controlled 4-month crossover trial in a referral center.</p><p></p><p><strong>Patients:</strong> Sixty adult hypopituitary patients with GHD and more than 3 yr of continuous GH replacement therapy (mean treatment duration, 10 yr) participated in the study.</p><p></p><p><strong>Intervention:</strong> Patients received GH or placebo.</p><p></p><p><strong>Main Outcome Measurements:</strong> We measured QoL using validated questionnaires; body composition using computer tomography, dual-energy x-ray absorptiometry, and bioelectrical impedance spectroscopy; and insulin sensitivity using the short insulin tolerance test.</p><p></p><p><strong>Results:</strong> Mean serum IGF-I decreased from 168± 52 to 98± 47 µg/liter during the placebo period (<em>P</em>< 0.001). Two QoL domains (emotional reactions and positive well-being) in the Nottingham Health Profile and Psychological General Well-Being questionnaires deteriorated during placebo, compared with GH treatment (<em>P</em>< 0.05). Waist circumference and sc and visceral fat mass increased, and extracellular water and muscle area decreased during the placebo period (all <em>P</em>< 0.05). C-reactive protein and total-, low-density lipoprotein-, and high-density lipoprotein-cholesterol increased, and insulin sensitivity improved during placebo, compared to GH treatment (<em>P</em>< 0.05).</p><p></p><p><strong>Conclusion:</strong> After more than 3 yr of GH replacement therapy, a 4-month period of placebo treatment caused self-perceived deterioration in QoL and increased abdominal fat accumulation. Moreover, markers of systemic inflammation and lipid status deteriorated, whereas insulin sensitivity improved. Long-term continuous GH replacement is needed to maintain therapeutic effects of GH on QoL and cardiovascular risk factors.</p></blockquote><p></p>
[QUOTE="Excel Male, post: 84, member: 1"] Study Looked at What Happens When Long Term Growth Hormone Replacement Therapy is Stopped [B]Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency[/B] Department of Endocrinology, Sahlgrenska University Hospital, and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-41345 Göteborg, Sweden [B]Abstract[/B] [B]Context:[/B] Adult GH deficiency (GHD) is associated with impaired quality of life (QoL) and increased cardiovascular risk. Continued long-term efficacy in terms of QoL and cardiovascular risk factors has been indicated in open surveillance studies. [B]Objectives:[/B] The aim was to study the impact of discontinuation of long-term GH replacement on QoL, body composition, and metabolism. [B]Design and Setting:[/B] We conducted a randomized, double-blind, placebo-controlled 4-month crossover trial in a referral center. [B]Patients:[/B] Sixty adult hypopituitary patients with GHD and more than 3 yr of continuous GH replacement therapy (mean treatment duration, 10 yr) participated in the study. [B]Intervention:[/B] Patients received GH or placebo. [B]Main Outcome Measurements:[/B] We measured QoL using validated questionnaires; body composition using computer tomography, dual-energy x-ray absorptiometry, and bioelectrical impedance spectroscopy; and insulin sensitivity using the short insulin tolerance test. [B]Results:[/B] Mean serum IGF-I decreased from 168± 52 to 98± 47 µg/liter during the placebo period ([I]P[/I]< 0.001). Two QoL domains (emotional reactions and positive well-being) in the Nottingham Health Profile and Psychological General Well-Being questionnaires deteriorated during placebo, compared with GH treatment ([I]P[/I]< 0.05). Waist circumference and sc and visceral fat mass increased, and extracellular water and muscle area decreased during the placebo period (all [I]P[/I]< 0.05). C-reactive protein and total-, low-density lipoprotein-, and high-density lipoprotein-cholesterol increased, and insulin sensitivity improved during placebo, compared to GH treatment ([I]P[/I]< 0.05). [B]Conclusion:[/B] After more than 3 yr of GH replacement therapy, a 4-month period of placebo treatment caused self-perceived deterioration in QoL and increased abdominal fat accumulation. Moreover, markers of systemic inflammation and lipid status deteriorated, whereas insulin sensitivity improved. Long-term continuous GH replacement is needed to maintain therapeutic effects of GH on QoL and cardiovascular risk factors. [/QUOTE]
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General Peptide Use & Information
What Happens When Long Term Growth Hormone is Stopped
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