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What happens to the carbs?
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<blockquote data-quote="croaker24" data-source="post: 20360" data-attributes="member: 900"><p>With respect to the ApoE genotype and lipids - the following summary is a succinct description of the research out there:</p><p></p><p><a href="http://www.clevelandheartlab.com/wp-content/uploads/2013/10/ApoE-Practitioner-OnePager-CHL-D023.pdf" target="_blank">http://www.clevelandheartlab.com/wp-content/uploads/2013/10/ApoE-Practitioner-OnePager-CHL-D023.pdf</a></p><p></p><p>For example - it states:</p><p></p><p>"The ApoE genotype can affect an individual’s response to lifestyle modifications. In those with the e2/e2 or e2/e3 genotype, extremely low fat diets can increase small dense LDL levels, and therefore these individuals should have moderate fat restriction.</p><p></p><p>Individuals with the e4/e3 or e4/e4 genotype, on the other hand, respond well to very low fat dietary restrictions.</p><p></p><p> Responsiveness to treatment with statins is also affected by the ApoE genotype. Individuals with the e2/e2 or e2/e3 genotype respond well to statins, while statins are less effective in individuals with the e4/e3 or e4/e4."</p><p></p><p>NOW - Alzheimer's also comes in to play. According to the following URL:</p><p></p><p><a href="http://www.alzdiscovery.org/cognitive-vitality/what-apoe-means-for-your-health" target="_blank">http://www.alzdiscovery.org/cognitive-vitality/what-apoe-means-for-your-health</a></p><p></p><p>"Given the baseline of e3/e3 as normal risk. Those with the e2 allele have 40% less risk of developing the disease. Those with the e3/e4 variants have 3.2 times greater. And those with e4/e4 have 14.9 times greater risk."</p><p></p><p>ALSO - e2/e2 genotype can be at elevated risk for Type III Hyperlipidemia - however - only a very small % of people with this genotype actually develop it.</p><p></p><p>My conclusions -</p><p></p><p>a) For the most part the evidence is not real strong for specific dietary recommendations, there's too many other factors involved. </p><p></p><p>b) Having said that, as an e2/e3 - it does appear I should avoid an extremely low-fat diet. Given I have very good LDL-P - I don't think this is an issue. And I definitely do not eat extremely low-fat.</p><p></p><p>c) If you are e3/e3 - no real specific diet is applicable. </p><p></p><p>d) If you are one of the extremes (e2/e2 or e4/e4) you very well may need a specific diet plan provided you have began developing pertinent symptoms. And should better be talking to specialists and not relying on google or naturopathic types for advice. </p><p></p><p>IMHO, getting this test done is unnecessary and likely a waste of money unless you are experiencing some pertinent conditions/symptoms such as cardiovascular issues, very high LDL/triglycerides etc. I would not presume to even advise with respect to Alzheimer's. I did not know I getting this test done by my previous TRT provider until after the fact when I was already in the lab having the blood drawn, as I did not read the prescription in detail. As such, I've had the test, I've read up on it - and it changes nothing. </p><p></p><p></p><p>.</p></blockquote><p></p>
[QUOTE="croaker24, post: 20360, member: 900"] With respect to the ApoE genotype and lipids - the following summary is a succinct description of the research out there: [URL]http://www.clevelandheartlab.com/wp-content/uploads/2013/10/ApoE-Practitioner-OnePager-CHL-D023.pdf[/URL] For example - it states: "The ApoE genotype can affect an individual’s response to lifestyle modifications. In those with the e2/e2 or e2/e3 genotype, extremely low fat diets can increase small dense LDL levels, and therefore these individuals should have moderate fat restriction. Individuals with the e4/e3 or e4/e4 genotype, on the other hand, respond well to very low fat dietary restrictions. Responsiveness to treatment with statins is also affected by the ApoE genotype. Individuals with the e2/e2 or e2/e3 genotype respond well to statins, while statins are less effective in individuals with the e4/e3 or e4/e4." NOW - Alzheimer's also comes in to play. According to the following URL: [URL]http://www.alzdiscovery.org/cognitive-vitality/what-apoe-means-for-your-health[/URL] "Given the baseline of e3/e3 as normal risk. Those with the e2 allele have 40% less risk of developing the disease. Those with the e3/e4 variants have 3.2 times greater. And those with e4/e4 have 14.9 times greater risk." ALSO - e2/e2 genotype can be at elevated risk for Type III Hyperlipidemia - however - only a very small % of people with this genotype actually develop it. My conclusions - a) For the most part the evidence is not real strong for specific dietary recommendations, there's too many other factors involved. b) Having said that, as an e2/e3 - it does appear I should avoid an extremely low-fat diet. Given I have very good LDL-P - I don't think this is an issue. And I definitely do not eat extremely low-fat. c) If you are e3/e3 - no real specific diet is applicable. d) If you are one of the extremes (e2/e2 or e4/e4) you very well may need a specific diet plan provided you have began developing pertinent symptoms. And should better be talking to specialists and not relying on google or naturopathic types for advice. IMHO, getting this test done is unnecessary and likely a waste of money unless you are experiencing some pertinent conditions/symptoms such as cardiovascular issues, very high LDL/triglycerides etc. I would not presume to even advise with respect to Alzheimer's. I did not know I getting this test done by my previous TRT provider until after the fact when I was already in the lab having the blood drawn, as I did not read the prescription in detail. As such, I've had the test, I've read up on it - and it changes nothing. . [/QUOTE]
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What happens to the carbs?
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