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What happens to the carbs?
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<blockquote data-quote="Vince" data-source="post: 20328" data-attributes="member: 843"><p>The point of the study is not that the assumption that "a diet high in saturated fat contributes to the development of CAD" in everyone. It's that depending on the type of Apo E alleles you have (3/3, 4/4, 2/2, or some other combination) that Apo E genotype will subtly define your LDL particle size and how you metabolize saturated fats. The conundrum with some folks whose Apo E genotype tends to turn dietary fat into a significant CAD risk is what to replace it with, i.e., either carbohydrate or protein. There really are no other choices. The whole point of the study is that one size does NOT fit all, and making generalizations about particular diets as being "heart healthy" cuts across all genotypes for Apo E, i.e., in some saturated fats <em>will</em> drive CAD, and in others not so much, and likewise, carbohydrate can lead to excess inflammation, fat storage, insulin resistance, etc., but so can large intakes of protein. Again, the issue is not that the analysis is misleading, it's that Apo E genotypes influence things in ways that make generalizations almost impossible.</p><p></p><p>From the article's conclusion:</p><p></p><p>In conclusion, our data indicate that <strong><u>each subject has to be examined and guided individually when dietary recommendations are made</u></strong>. <strong><u>No diet can be recommended unequivocally without knowing more about those being targeted</u></strong>. Even though a MUFA-rich diet increases LDL size compared with a CHO-rich diet, this effect is dependent on apoE genotypes. Thus, the replacement of a CHO diet by a MUFA diet increases LDL-size in apoE 3/3, whereas it decreases it in apoE 4/3 subjects.</p><p></p><p> That said, there is recently emerging data which demonstrates that some saturated fats (e.g., fermented cheeses for one) are quite protective, and do not contribute to the development of CAD, and may actually do quite the opposite by increasing circulating serum K-2 (of the MK-7 variety, if you eat the right cheeses). There are many who swear by organ meats such as liver, kidney, etc., but I have to say, I'm not one of them.</p></blockquote><p></p>
[QUOTE="Vince, post: 20328, member: 843"] The point of the study is not that the assumption that "a diet high in saturated fat contributes to the development of CAD" in everyone. It's that depending on the type of Apo E alleles you have (3/3, 4/4, 2/2, or some other combination) that Apo E genotype will subtly define your LDL particle size and how you metabolize saturated fats. The conundrum with some folks whose Apo E genotype tends to turn dietary fat into a significant CAD risk is what to replace it with, i.e., either carbohydrate or protein. There really are no other choices. The whole point of the study is that one size does NOT fit all, and making generalizations about particular diets as being "heart healthy" cuts across all genotypes for Apo E, i.e., in some saturated fats [I]will[/I] drive CAD, and in others not so much, and likewise, carbohydrate can lead to excess inflammation, fat storage, insulin resistance, etc., but so can large intakes of protein. Again, the issue is not that the analysis is misleading, it's that Apo E genotypes influence things in ways that make generalizations almost impossible. From the article's conclusion: In conclusion, our data indicate that [B][U]each subject has to be examined and guided individually when dietary recommendations are made[/U][/B]. [B][U]No diet can be recommended unequivocally without knowing more about those being targeted[/U][/B]. Even though a MUFA-rich diet increases LDL size compared with a CHO-rich diet, this effect is dependent on apoE genotypes. Thus, the replacement of a CHO diet by a MUFA diet increases LDL-size in apoE 3/3, whereas it decreases it in apoE 4/3 subjects. That said, there is recently emerging data which demonstrates that some saturated fats (e.g., fermented cheeses for one) are quite protective, and do not contribute to the development of CAD, and may actually do quite the opposite by increasing circulating serum K-2 (of the MK-7 variety, if you eat the right cheeses). There are many who swear by organ meats such as liver, kidney, etc., but I have to say, I'm not one of them. [/QUOTE]
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What happens to the carbs?
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