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What happens to the carbs?
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<blockquote data-quote="Vince" data-source="post: 20327" data-attributes="member: 843"><p>Nutrient-Gene Interactions</p><p><strong>The Effect of Dietary Fat on LDL Size Is Influenced by Apolipoprotein E Genotype in Healthy Subjects</strong></p><p></p><p><strong>Juan Antonio Moreno, Francisco Pérez-Jiménez, Carmen Marín, Purificación Gómez, Pablo Pérez-Martínez, Rafael Moreno, Cecilia Bellido, Francisco Fuentes and José López-Miranda</strong></p><p><strong></strong></p><p><em>Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofía, Córdoba, Spain </em></p><p> </p><p></p><p>LDL particle size is dependent on both genetic factors and environmentalfactors such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major genetic determinant of LDL size.Thus, the aim of this work was to study whether the <em>apoE</em> genotype interacts with the quantity and quality of dietary fat, modifying LDL size in young healthy subjects. Healthy subjects (<em>n</em> = 84;66 apoE 3/3, 8 apoE 4/3, 10 apoE 3/2) were subjected to 3 dietary periods, each lasting 4 wk. The first was an SFA-enriched diet(38% fat, 20% SFA), which was followed by a carbohydrate (CHO)-rich[SUP][[/SUP]diet (30% fat, < 10% SFA, 55% carbohydrate) or a monounsaturated fatty acid (MUFA) olive oil–rich diet (38% fat, 22% MUFA)following a randomized crossover design. At the end of each diet period, LDL particle size and plasma levels of total cholesterol,LDL cholesterol (LDL-C), HDL-C, apoB, apoA-I, and triacylglycerols were determined. LDL particle size was significantly higher(<em>P</em> < 0.04) in subjects with the apoE 4/3 genotype compared with those with apoE 3/3 and apoE 3/2 in the basal state. LDL size was smaller (<em>P</em> < 0.02) after the CHO diet than after [SUP]][/SUP]the MUFA or SFA diets. After the CHO diet, a significant increase in LDL particle size (<em>P</em> < 0.035) was noted with respect tothe MUFA diet in apoE 4/3 subjects, whereas a significant decrease was observed in the apoE 3/3 individuals (<em>P</em> < 0.043). In conclusion, a Mediterranean diet, high in MUFA-fat increases LDL particle size compared with a CHO diet, and this effect is dependent of apoE genotypes.</p></blockquote><p></p>
[QUOTE="Vince, post: 20327, member: 843"] Nutrient-Gene Interactions [B]The Effect of Dietary Fat on LDL Size Is Influenced by Apolipoprotein E Genotype in Healthy Subjects[/B] [B]Juan Antonio Moreno, Francisco Pérez-Jiménez, Carmen Marín, Purificación Gómez, Pablo Pérez-Martínez, Rafael Moreno, Cecilia Bellido, Francisco Fuentes and José López-Miranda [/B] [I]Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofía, Córdoba, Spain [/I] LDL particle size is dependent on both genetic factors and environmentalfactors such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major genetic determinant of LDL size.Thus, the aim of this work was to study whether the [I]apoE[/I] genotype interacts with the quantity and quality of dietary fat, modifying LDL size in young healthy subjects. Healthy subjects ([I]n[/I] = 84;66 apoE 3/3, 8 apoE 4/3, 10 apoE 3/2) were subjected to 3 dietary periods, each lasting 4 wk. The first was an SFA-enriched diet(38% fat, 20% SFA), which was followed by a carbohydrate (CHO)-rich[SUP][[/SUP]diet (30% fat, < 10% SFA, 55% carbohydrate) or a monounsaturated fatty acid (MUFA) olive oil–rich diet (38% fat, 22% MUFA)following a randomized crossover design. At the end of each diet period, LDL particle size and plasma levels of total cholesterol,LDL cholesterol (LDL-C), HDL-C, apoB, apoA-I, and triacylglycerols were determined. LDL particle size was significantly higher([I]P[/I] < 0.04) in subjects with the apoE 4/3 genotype compared with those with apoE 3/3 and apoE 3/2 in the basal state. LDL size was smaller ([I]P[/I] < 0.02) after the CHO diet than after [SUP]][/SUP]the MUFA or SFA diets. After the CHO diet, a significant increase in LDL particle size ([I]P[/I] < 0.035) was noted with respect tothe MUFA diet in apoE 4/3 subjects, whereas a significant decrease was observed in the apoE 3/3 individuals ([I]P[/I] < 0.043). In conclusion, a Mediterranean diet, high in MUFA-fat increases LDL particle size compared with a CHO diet, and this effect is dependent of apoE genotypes. [/QUOTE]
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What happens to the carbs?
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