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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What happens to all the oil we inject?
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<blockquote data-quote="TMI" data-source="post: 77013" data-attributes="member: 13990"><p>[ATTACH]3886[/ATTACH]Interstitial macrophages clean up all that grapeseed oil. Same cells (different location) that scavenge lipoprotein deposits on arterial walls and lead the myocardial infarction. In the latter setting, they're referred to as foam cells.</p><p></p><p>They're also known as histiocytes and giant cells, depending on their stage of differentiation (I'm not a histologist). Lymphocytes may join them in the inflammatory response.</p><p></p><p>If you've ever noted prolonged tenderness, swelling, and induration (firmness) of the tissues at and around a subcutaneous injection site - that was likely due to inflammation from cells that include these macrophages. This inflammation may be so severe that that subcutaneous cells (adipocytes, fibroblasts, etc.) die - and they may eventually even become calcified (see MRI attached - <a href="https://radiopaedia.org/articles/gluteal-injection-site-granuloma" target="_blank">https://radiopaedia.org/articles/gluteal-injection-site-granuloma</a>). </p><p></p><p>This is generally a local response, but I'm no expert and really have no idea about any of this, and this is not advice. Always inject per the instructions given to you by your doctor, nurse practitioner, physician assistant, pharmacisist, pharmacy tech, and any documentation such as package inserts that my accompany your prescription medication.</p></blockquote><p></p>
[QUOTE="TMI, post: 77013, member: 13990"] [ATTACH=CONFIG]3886[/ATTACH]Interstitial macrophages clean up all that grapeseed oil. Same cells (different location) that scavenge lipoprotein deposits on arterial walls and lead the myocardial infarction. In the latter setting, they're referred to as foam cells. They're also known as histiocytes and giant cells, depending on their stage of differentiation (I'm not a histologist). Lymphocytes may join them in the inflammatory response. If you've ever noted prolonged tenderness, swelling, and induration (firmness) of the tissues at and around a subcutaneous injection site - that was likely due to inflammation from cells that include these macrophages. This inflammation may be so severe that that subcutaneous cells (adipocytes, fibroblasts, etc.) die - and they may eventually even become calcified (see MRI attached - [URL]https://radiopaedia.org/articles/gluteal-injection-site-granuloma[/URL]). This is generally a local response, but I'm no expert and really have no idea about any of this, and this is not advice. Always inject per the instructions given to you by your doctor, nurse practitioner, physician assistant, pharmacisist, pharmacy tech, and any documentation such as package inserts that my accompany your prescription medication. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What happens to all the oil we inject?
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