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I have low SHBG - it was 12 in my last bloodwork - and that is pretty much where it's been for the previous ten years, but I have no trace of metabolic syndrome, and I am not diabetic or pre-diabetic.

With low SHBG, I do not "feel" my TRT at all. On TRT and with good blood numbers for free T, total T, and E2, I still have low libido, and can't build any muscle or lose any fat. It is like being "low T" even while on TRT. Oh, and guys that think low SHBG is "better" and builds more muscle need to walk a mile in the shoes of someone with low SHBG. We would not wish it on our worst enemies.

The only reason I am still on TRT is that I know it's healthier long-term to have normal T vs. low T.

[QUOTE="ERO, post: 212111, member: 1210"] I have low SHBG - it was 12 in my last bloodwork - and that is pretty much where it's been for the previous ten years, but I have no trace of metabolic syndrome, and I am not diabetic or pre-diabetic. With low SHBG, I do not "feel" my TRT at all. On TRT and with good blood numbers for free T, total T, and E2, I still have low libido, and can't build any muscle or lose any fat. It is like being "low T" even while on TRT. Oh, and guys that think low SHBG is "better" and builds more muscle need to walk a mile in the shoes of someone with low SHBG. We would not wish it on our worst enemies. The only reason I am still on TRT is that I know it's healthier long-term to have normal T vs. low T. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038