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Wellbutrin works fine in addition to TRT. There is no interaction between the two. It’s a good first choice for attempting to treat depression because it does not come with many of the side effects that the SSRI drugs do. From personal experience, it lets your mood go up, but helps you hold steady instead of going down. So you can still feel all the happiness and pleasure, etc. compared to a SSRI which holds your mood in a sort of neutral zone commonly making people feel like a robot who can’t be happy or sad. Wellbutrin also is not known to have a negative effect on libido and may in fact increase it. It is a stimulant and sometimes prescribed for weight loss because it acts as an appetite suppressant