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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Well, this can't be good, high dose aas >>>Dementia
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<blockquote data-quote="maxadvance" data-source="post: 140351" data-attributes="member: 12434"><p><span style="font-size: 26px"><strong>Supraphysiologic-dose anabolic-androgenic steroid use: a risk factor for dementia?</strong></span></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kaufman%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=30817935" target="_blank">Kaufman MJ</a>1, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Kanayama%20G%5BAuthor%5D&cauthor=true&cauthor_uid=30817935" target="_blank">Kanayama G</a>2, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Hudson%20JI%5BAuthor%5D&cauthor=true&cauthor_uid=30817935" target="_blank">Hudson JI</a>2, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Pope%20HG%5BAuthor%5D&cauthor=true&cauthor_uid=30817935" target="_blank">Pope HG</a>2.</p><p><span style="font-size: 18px"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/30817935?fbclid=IwAR3lAUaM9ima6OQoDYaCyYnbJizi0_jetMmZMu3A_8nBOVBAACdeE_Y2P1Y#" target="_blank">Author information</a></strong></span></p><p></p><p><span style="font-size: 18px"><strong>Abstract</strong></span></p><p>Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. Supraphysiologic-dose AAS induces androgen abnormalities and excess oxidative stress, which have been linked to increased and decreased expression or activity of proteins that synthesize and eliminate, respectively, Aβ and tau-P. Aβ and tau-P accumulation may begin soon after initiating supraphysiologic-dose AAS use, which typically occurs in the early 20s, and their accumulation may be accelerated by other psychoactive substance use, which is common among non-medical AAS users. Accordingly, the widespread use of supraphysiologic-dose AAS may increase the numbers of people who develop dementia. Early diagnosis and correction of sex-steroid level abnormalities and excess oxidative stress could attenuate risk for developing AD/ADRD in supraphysiologic-dose AAS users, in people with other substance use disorders, and in people with low sex-steroid levels or excess oxidative stress associated with aging.</p><p>Copyright © 2019 Elsevier Ltd. All rights reserved.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/30817935?fbclid=IwAR3lAUaM9ima6OQoDYaCyYnbJizi0_jetMmZMu3A_8nBOVBAACdeE_Y2P1Y" target="_blank">Supraphysiologic-dose anabolic-androgenic steroid use: a risk factor for dementia? - PubMed - NCBI</a></p></blockquote><p></p>
[QUOTE="maxadvance, post: 140351, member: 12434"] [SIZE=26px][B]Supraphysiologic-dose anabolic-androgenic steroid use: a risk factor for dementia?[/B][/SIZE] [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Kaufman%20MJ%5BAuthor%5D&cauthor=true&cauthor_uid=30817935']Kaufman MJ[/URL]1, [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Kanayama%20G%5BAuthor%5D&cauthor=true&cauthor_uid=30817935']Kanayama G[/URL]2, [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Hudson%20JI%5BAuthor%5D&cauthor=true&cauthor_uid=30817935']Hudson JI[/URL]2, [URL='https://www.ncbi.nlm.nih.gov/pubmed/?term=Pope%20HG%5BAuthor%5D&cauthor=true&cauthor_uid=30817935']Pope HG[/URL]2. [SIZE=18px][B][URL='https://www.ncbi.nlm.nih.gov/pubmed/30817935?fbclid=IwAR3lAUaM9ima6OQoDYaCyYnbJizi0_jetMmZMu3A_8nBOVBAACdeE_Y2P1Y#']Author information[/URL][/B][/SIZE] [SIZE=18px][B]Abstract[/B][/SIZE] Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. Supraphysiologic-dose AAS induces androgen abnormalities and excess oxidative stress, which have been linked to increased and decreased expression or activity of proteins that synthesize and eliminate, respectively, Aβ and tau-P. Aβ and tau-P accumulation may begin soon after initiating supraphysiologic-dose AAS use, which typically occurs in the early 20s, and their accumulation may be accelerated by other psychoactive substance use, which is common among non-medical AAS users. Accordingly, the widespread use of supraphysiologic-dose AAS may increase the numbers of people who develop dementia. Early diagnosis and correction of sex-steroid level abnormalities and excess oxidative stress could attenuate risk for developing AD/ADRD in supraphysiologic-dose AAS users, in people with other substance use disorders, and in people with low sex-steroid levels or excess oxidative stress associated with aging. Copyright © 2019 Elsevier Ltd. All rights reserved. [URL="https://www.ncbi.nlm.nih.gov/pubmed/30817935?fbclid=IwAR3lAUaM9ima6OQoDYaCyYnbJizi0_jetMmZMu3A_8nBOVBAACdeE_Y2P1Y"]Supraphysiologic-dose anabolic-androgenic steroid use: a risk factor for dementia? - PubMed - NCBI[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Well, this can't be good, high dose aas >>>Dementia
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