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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Weekly administration of anabolic steroids improved symptoms of COPD
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<blockquote data-quote="Nelson Vergel" data-source="post: 6161" data-attributes="member: 3"><p><em>[ATTACH]616[/ATTACH]</em></p><p><em></em></p><p><em></em></p><p><em>Background</em>: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and is associated with weight loss and decreased muscle strength and exercise capacity. </p><p><em></em></p><p><em>Methods</em>: A double-blinded randomized controlled trial of 32 male COPD patients (age, 54.94 ± 11.27 years) was carried out to assess effects of anabolic steroid in terms of a daily high-protein, high-calorie diet alone or one combined with anabolic steroids on body composition, lung function, and health-related quality of life (HRQL). Outcomes were assessed by anthropometric and spirometric measurements, peak expiratory flow rate, partial pressure of oxygen in arterial blood, 6-minute walk test (6MWT), hand grip test, and HRQL index scores. Measurements were made at baseline and end of treatment (6 weeks). </p><p><em></em></p><p><em>Results</em>: All patients showed significant difference (<em>P</em> < .001) in pulmonary function parameters and anthropometric measurements after 6 weeks of intervention (within-group changes); however, no significant improvement occurred in the pulmonary function parameters between the groups. The difference in exercise capacity (6MWT) and HRQL scores in the treatment group were statistically significant (<em>P</em> < .001) compared with control group after 6 weeks of intervention. In the treatment group, the average 6MWT distance increased from 213.5 m to 268.5 m at 6-week follow-up, and HRQL scores increased from 101.25 to 118.45. Also, HRQL and 6MWT parameters were positively correlated in response to steroid supplementation at the end of the study. </p><p><em></em></p><p><em>Conclusion</em>: Weekly administration of anabolic steroids during 6 weeks increased exercise capacity and quality of life in patients with COPD.</p><p></p><p><a href="http://ncp.sagepub.com/content/early/2014/02/18/0884533614522832.abstract" target="_blank">http://ncp.sagepub.com/content/early/2014/02/18/0884533614522832.abstract</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 6161, member: 3"] [I][ATTACH=CONFIG]616[/ATTACH] Background[/I]: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and is associated with weight loss and decreased muscle strength and exercise capacity. [I] Methods[/I]: A double-blinded randomized controlled trial of 32 male COPD patients (age, 54.94 ± 11.27 years) was carried out to assess effects of anabolic steroid in terms of a daily high-protein, high-calorie diet alone or one combined with anabolic steroids on body composition, lung function, and health-related quality of life (HRQL). Outcomes were assessed by anthropometric and spirometric measurements, peak expiratory flow rate, partial pressure of oxygen in arterial blood, 6-minute walk test (6MWT), hand grip test, and HRQL index scores. Measurements were made at baseline and end of treatment (6 weeks). [I] Results[/I]: All patients showed significant difference ([I]P[/I] < .001) in pulmonary function parameters and anthropometric measurements after 6 weeks of intervention (within-group changes); however, no significant improvement occurred in the pulmonary function parameters between the groups. The difference in exercise capacity (6MWT) and HRQL scores in the treatment group were statistically significant ([I]P[/I] < .001) compared with control group after 6 weeks of intervention. In the treatment group, the average 6MWT distance increased from 213.5 m to 268.5 m at 6-week follow-up, and HRQL scores increased from 101.25 to 118.45. Also, HRQL and 6MWT parameters were positively correlated in response to steroid supplementation at the end of the study. [I] Conclusion[/I]: Weekly administration of anabolic steroids during 6 weeks increased exercise capacity and quality of life in patients with COPD. [url]http://ncp.sagepub.com/content/early/2014/02/18/0884533614522832.abstract[/url] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Weekly administration of anabolic steroids improved symptoms of COPD
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