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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention While on TRT May Only Occur to Certain Men
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<blockquote data-quote="Nelson Vergel" data-source="post: 212940" data-attributes="member: 3"><p>He failed to mention why growth hormone (with no effect on estrogen) increases water retention, or why stanozolol or oxandrolone (DHT analogs, lower estrogen) can also cause water retention.</p><p>The effects of GH and androgens on RAAS is extremely pronounced even in the absence of estrogen.</p><p>The slide he used comes from a lecture about women and HRT risks (high estrogen and progesterone). Our estrogen and progesterone levels are much lower and our testosterone levels are much higher. Increased renal reabsorption of sodium is what is behind water retention, specially with androgens.</p><p></p><p>If estrogen was the main factor involved in water retention in men on TRT, then anastrozole would completely get rid off this issue. It does not. The only effective way to reduce water retention is:</p><p></p><p>1- Reduction of TRT dose/frequency</p><p>2- Lower comsumption of salt and sweets (which increase insulin and water retention)</p><p>3- Using diuretics</p><p></p><p>Here is the source of his main slide:</p><p>[URL unfurl="true"]https://slidetodoc.com/la-drospirenona-em-la-menopausia-terapia-hormonal-basada/[/URL]</p><p></p><p>From post #9 above:</p><p></p><p>The effects of testosterone on the volume and distribution of ECW <strong>could theoretically occur secondary to aromatization to estrogen in peripheral tissues.</strong> <strong>Estrogen may cause fluid retention through reduction of the plasma antidiuretic hormone (arginine vasopressin)-plasma osmolality set point (39, 40) or stimulating the synthesis of hepatic angiotensinogen (41), enhancing the overall activity of RAAS and leading to sodium retention.</strong> However, <strong>this postulate is not supported</strong> by the observation that <u>urinary sodium excretion is increased during oral contraceptive use (42) or that the plasma renin concentration is reduced in women receiving estrogen treatment (43).</u> Moreover, estrogen reduces the plasma renin concentration, the activity of angiotensin-converting enzyme, and the Aldo response to angiotensin II (44, 45). <strong>These actions of estrogen putatively generated from aromatization of androgens could explain the slight reduction in plasma Aldo levels in response to testosterone in our study." <a href="https://academic.oup.com/jcem/article/90/7/3989/2837248/Independent-and-Combined-Effects-of-Testosterone" target="_blank">Source</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 212940, member: 3"] He failed to mention why growth hormone (with no effect on estrogen) increases water retention, or why stanozolol or oxandrolone (DHT analogs, lower estrogen) can also cause water retention. The effects of GH and androgens on RAAS is extremely pronounced even in the absence of estrogen. The slide he used comes from a lecture about women and HRT risks (high estrogen and progesterone). Our estrogen and progesterone levels are much lower and our testosterone levels are much higher. Increased renal reabsorption of sodium is what is behind water retention, specially with androgens. If estrogen was the main factor involved in water retention in men on TRT, then anastrozole would completely get rid off this issue. It does not. The only effective way to reduce water retention is: 1- Reduction of TRT dose/frequency 2- Lower comsumption of salt and sweets (which increase insulin and water retention) 3- Using diuretics Here is the source of his main slide: [URL unfurl="true"]https://slidetodoc.com/la-drospirenona-em-la-menopausia-terapia-hormonal-basada/[/URL] From post #9 above: The effects of testosterone on the volume and distribution of ECW [B]could theoretically occur secondary to aromatization to estrogen in peripheral tissues.[/B] [B]Estrogen may cause fluid retention through reduction of the plasma antidiuretic hormone (arginine vasopressin)-plasma osmolality set point (39, 40) or stimulating the synthesis of hepatic angiotensinogen (41), enhancing the overall activity of RAAS and leading to sodium retention.[/B] However, [B]this postulate is not supported[/B] by the observation that [U]urinary sodium excretion is increased during oral contraceptive use (42) or that the plasma renin concentration is reduced in women receiving estrogen treatment (43).[/U] Moreover, estrogen reduces the plasma renin concentration, the activity of angiotensin-converting enzyme, and the Aldo response to angiotensin II (44, 45). [B]These actions of estrogen putatively generated from aromatization of androgens could explain the slight reduction in plasma Aldo levels in response to testosterone in our study." [URL='https://academic.oup.com/jcem/article/90/7/3989/2837248/Independent-and-Combined-Effects-of-Testosterone']Source[/URL][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention While on TRT May Only Occur to Certain Men
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