ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 86017" data-attributes="member: 3"><p>This may be the reason I feel less bloated on metformin.</p><p></p><p>Metformin increases in vivo 11β-hydroxysteroid dehydrogenase type 1 activity in euglycaemic obese men</p><p></p><p>Endocrine Abstracts (2011) 25 OC2.8 </p><p>|</p><p>Roland Stimson, Ruth Andrew, Gregory Jones, Dawn Livingstone, Kenneth Smith & Brian Walker</p><p></p><p>Author affiliations</p><p>Inhibiting cortisol regeneration by 11β-HSD1 is a promising therapy for type two diabetes. In obesity, 11β-HSD1 activity is increased in adipose tissue but decreased in the liver, the latter putatively mediated by hyperinsulinaemia. We tested whether insulin sensitisation with metformin regulates 11β-HSD1 activity in whole body and in liver in obesity.</p><p></p><p>Five obese men (age 48±5 years, BMI 39.8±3.6 kg/m2) participated in a randomised, double-blinded, crossover study comparing metformin (1 g BD orally for 28 days) with placebo. At the end of each phase, subjects collected a 24 h urine sample and attended twice after overnight fast. On a first visit, 9,11,12,12-[2H]4-cortisol (d4-cortisol) was infused for 4 h, with repeated blood sampling to measure steady state d3-cortisol appearance (whole body 11β-HSD1 activity). On a second visit, subjects took 0.25 mg oral dexamethasone at 2300 h and 25 mg oral cortisone at 0900 h, with repeated blood sampling to measure conversion to cortisol by hepatic 11β-HSD1. Steroids were quantified by RIA (cortisone test) or mass spectrometry (tracer and urinary steroids). Local ethical approval was obtained. Data are mean±S.E.M.</p><p></p><p>Fasting glucose (5.3±0.3 vs 6.0±0.9 mmol/l) and insulin (11.4±3.5 vs 21.0±7.8 mU/l) were non-significantly decreased by metformin. Metformin increased whole body rate of appearance of d3-cortisol (48±6 vs 39±5 nmol/min, P=0.01), but did not alter the rate of conversion of oral cortisone to cortisol (area under curve 29 951±11 207 vs 34 128±3741, P=0.7) or urinary cortisol metabolites (15.9±4.0 vs 18.3±4.2 mg/day).</p><p></p><p>Metformin increases whole body 11β-HSD1 activity in euglycaemic obese men. However, whether this is mediated in the liver by reversal of hyperinsulinaemia remains unproven. There has been concern that 11β-HSD1 inhibitors will be less effective in the presence of metformin, given their shared mechanism of suppressing hepatic gluconeogenesis. These data suggest, however, that metformin may increase the local regeneration of cortisol by 11β-HSD1 and provide a bigger target for 11β-HSD1 inhibitors.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 86017, member: 3"] This may be the reason I feel less bloated on metformin. Metformin increases in vivo 11β-hydroxysteroid dehydrogenase type 1 activity in euglycaemic obese men Endocrine Abstracts (2011) 25 OC2.8 | Roland Stimson, Ruth Andrew, Gregory Jones, Dawn Livingstone, Kenneth Smith & Brian Walker Author affiliations Inhibiting cortisol regeneration by 11β-HSD1 is a promising therapy for type two diabetes. In obesity, 11β-HSD1 activity is increased in adipose tissue but decreased in the liver, the latter putatively mediated by hyperinsulinaemia. We tested whether insulin sensitisation with metformin regulates 11β-HSD1 activity in whole body and in liver in obesity. Five obese men (age 48±5 years, BMI 39.8±3.6 kg/m2) participated in a randomised, double-blinded, crossover study comparing metformin (1 g BD orally for 28 days) with placebo. At the end of each phase, subjects collected a 24 h urine sample and attended twice after overnight fast. On a first visit, 9,11,12,12-[2H]4-cortisol (d4-cortisol) was infused for 4 h, with repeated blood sampling to measure steady state d3-cortisol appearance (whole body 11β-HSD1 activity). On a second visit, subjects took 0.25 mg oral dexamethasone at 2300 h and 25 mg oral cortisone at 0900 h, with repeated blood sampling to measure conversion to cortisol by hepatic 11β-HSD1. Steroids were quantified by RIA (cortisone test) or mass spectrometry (tracer and urinary steroids). Local ethical approval was obtained. Data are mean±S.E.M. Fasting glucose (5.3±0.3 vs 6.0±0.9 mmol/l) and insulin (11.4±3.5 vs 21.0±7.8 mU/l) were non-significantly decreased by metformin. Metformin increased whole body rate of appearance of d3-cortisol (48±6 vs 39±5 nmol/min, P=0.01), but did not alter the rate of conversion of oral cortisone to cortisol (area under curve 29 951±11 207 vs 34 128±3741, P=0.7) or urinary cortisol metabolites (15.9±4.0 vs 18.3±4.2 mg/day). Metformin increases whole body 11β-HSD1 activity in euglycaemic obese men. However, whether this is mediated in the liver by reversal of hyperinsulinaemia remains unproven. There has been concern that 11β-HSD1 inhibitors will be less effective in the presence of metformin, given their shared mechanism of suppressing hepatic gluconeogenesis. These data suggest, however, that metformin may increase the local regeneration of cortisol by 11β-HSD1 and provide a bigger target for 11β-HSD1 inhibitors. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top