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Great question!!


Lasix (furosemide ) increases insulin resistance and blood glucose. Insulin resistance has been associated with fat and lipid increases. Lasix can also decrease potassium and magnesium.



Furosemide-induced glucose intolerance in mice is associated with reduced insulin secretion - ScienceDirect



Eplerenone does not cause insulin resistance. The only problem is for those with eGFR (kidney function) under 30. They can have increases in potassium.



Effect of eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in patients with chronic heart failure - ScienceDirect


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