ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 52599" data-attributes="member: 3"><p><span style="font-size: 15px">I will be trying this drug soon to see the effect on mild water retention, bloating and BP increase that sometimes I get on HCG + TRT. <span style="color: #323232">Eplerenone is a selective aldosterone blocker (SAB) approved for the treatment of essential hypertension. It works like </span><span style="color: #555555">Spironolactone but without the testosterone lowering effects.</span></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"><strong><a href="http://www.nejm.org/doi/full/10.1056/NEJMoa030207#t=article" target="_blank">Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction</a></strong></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"><strong>"</strong><span style="color: #000000">Eplerenone is a next-generation mineralocorticoid antagonist. Like spironolactone it acts as a diuretic and helps to prevent mineralocorticoid-induced cardiovascular damage and reduces high blood pressure. Like spironolactone, eplerenone can cause a dangerous build-up of potassium in the blood (called hyperkalemia) so extreme care must be taken when using these drugs. Unlike spironolactone, eplerenone has no antagonist activity at the androgen receptor so it is unlikely to cause gynecomastia. Eplerenone is virtually unknown in the steroid using public because it is very new and is not available in generic form. Epleronone has distinct advantages over spironolactone but like other brand name only medications, is much more expensive than the readily available generic versions of spironolactone. The inhibition of 11-beta hydroxylase by certain AAS results in elevated levels of deoxycorticosterone in the blood. Deoxycorticosterone is a mineralocorticoid and will result in sodium and water retention, high blood pressure and adverse cardiovascular effects. Employing a mineralocorticoid antagonist could, theoretically, reduce these side effects of those AAS that inhibit 11-beta hydroxylase. The largest concern in doing so would be the potential for hyperkalemia with the use of antimineralocorticoids since some AAS have been reported to cause potassium retention as well."</span></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"><a href="http://mindandmuscle.net/articles/eplerenone/" target="_blank">http://mindandmuscle.net/articles/eplerenone/</a></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px"></span></p><p><span style="font-size: 15px">Note: High potassium can happen in men with low kidney function.</span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 52599, member: 3"] [SIZE=15px]I will be trying this drug soon to see the effect on mild water retention, bloating and BP increase that sometimes I get on HCG + TRT. [COLOR=#323232]Eplerenone is a selective aldosterone blocker (SAB) approved for the treatment of essential hypertension. It works like [/COLOR][COLOR=#555555]Spironolactone but without the testosterone lowering effects.[/COLOR] [B][URL='http://www.nejm.org/doi/full/10.1056/NEJMoa030207#t=article']Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction[/URL][/B] [B]"[/B][COLOR=#000000]Eplerenone is a next-generation mineralocorticoid antagonist. Like spironolactone it acts as a diuretic and helps to prevent mineralocorticoid-induced cardiovascular damage and reduces high blood pressure. Like spironolactone, eplerenone can cause a dangerous build-up of potassium in the blood (called hyperkalemia) so extreme care must be taken when using these drugs. Unlike spironolactone, eplerenone has no antagonist activity at the androgen receptor so it is unlikely to cause gynecomastia. Eplerenone is virtually unknown in the steroid using public because it is very new and is not available in generic form. Epleronone has distinct advantages over spironolactone but like other brand name only medications, is much more expensive than the readily available generic versions of spironolactone. The inhibition of 11-beta hydroxylase by certain AAS results in elevated levels of deoxycorticosterone in the blood. Deoxycorticosterone is a mineralocorticoid and will result in sodium and water retention, high blood pressure and adverse cardiovascular effects. Employing a mineralocorticoid antagonist could, theoretically, reduce these side effects of those AAS that inhibit 11-beta hydroxylase. The largest concern in doing so would be the potential for hyperkalemia with the use of antimineralocorticoids since some AAS have been reported to cause potassium retention as well."[/COLOR] [URL]http://mindandmuscle.net/articles/eplerenone/[/URL] Note: High potassium can happen in men with low kidney function.[/SIZE] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top