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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
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<blockquote data-quote="Digghy" data-source="post: 101069" data-attributes="member: 17900"><p>Dear all, I have read everything about this problem on many forums without finding a solution.</p><p></p><p></p><p>I am 36 years old, practicing body building since I was 24. I have a quite stressing work (top manager) and plus a very active lifestyle (train every day 2 hours in the morning with weight-lifting + 1,5 hours of cardio in the evening). I eat clean (proteins+vegetables with a low carb diet) with a cheat meal only once a week.</p><p></p><p></p><p>I had 2 blood tests in may 2017 and september 2017 showing testosterone in the low range (290 over a range 280-900), with cortisol on the high range (18 over a range 7-19) and ACTH well above the max value (88 with a max of 46), and my doctor started a 3 months teraphy with Testim Gel (transdermal, 50 mg per day, meaning 5 mg of effective testosterone per day). The first month I felt great, good energy, good drive, my body shape was good as usual (8-10% body fat), but after that I started bloating and retaining water, my abs just disappeared, despite my diet and my training were always the same as before.</p><p></p><p></p><p>I did blood test on January 2018 just at the end of the 3 months TRT period: estradiol was low, so no problem of aromatization, of course LH/FSH at 0, but ACTH increased to 118 and Aldosterone at the high top of the range (292 over a max of 295), despite my blood sodium and potassium were in range. </p><p></p><p></p><p>I used gonadorelins to restart my HPTA, after 6 weeks I did a blood test again showing a testosterone at the same level pre TRT (286), LH/FSH restarted, Aldosterone still at the top of the range, ACTH still at 109, cortisol in range (16 over a range 7-19). Still, bloated and full of water retention, in particolar after a workput or after eating.</p><p></p><p></p><p>I tried Eplenerone (25 mg and 50 mg), Metformine, Potassium... Nothing worked.</p><p></p><p></p><p>I found this article about testosterone inhibiting 11 HSD2 therefore with cortisol binding MR. I think this is my case: testosterone in presence of high ACTH and realtively high cortisol made this cortisol binding MR and making me retaining water.</p><p></p><p></p><p>There are now some questions:</p><p>- how is it possible that my sodium/potassium in blood test are in range?</p><p>- shouldn't I have high sodium and low potassium due to this activity on MR?</p><p>- how long does it take for 11 HSD2 to reactivate and MR to unbind from cortisol?</p><p>- there is something other I can do?</p><p></p><p></p><p>Now I am 2 months off from my TRT but still bloated and full of water.</p><p></p><p></p><p>Would very very thankful if some can give me your advice.</p></blockquote><p></p>
[QUOTE="Digghy, post: 101069, member: 17900"] Dear all, I have read everything about this problem on many forums without finding a solution. I am 36 years old, practicing body building since I was 24. I have a quite stressing work (top manager) and plus a very active lifestyle (train every day 2 hours in the morning with weight-lifting + 1,5 hours of cardio in the evening). I eat clean (proteins+vegetables with a low carb diet) with a cheat meal only once a week. I had 2 blood tests in may 2017 and september 2017 showing testosterone in the low range (290 over a range 280-900), with cortisol on the high range (18 over a range 7-19) and ACTH well above the max value (88 with a max of 46), and my doctor started a 3 months teraphy with Testim Gel (transdermal, 50 mg per day, meaning 5 mg of effective testosterone per day). The first month I felt great, good energy, good drive, my body shape was good as usual (8-10% body fat), but after that I started bloating and retaining water, my abs just disappeared, despite my diet and my training were always the same as before. I did blood test on January 2018 just at the end of the 3 months TRT period: estradiol was low, so no problem of aromatization, of course LH/FSH at 0, but ACTH increased to 118 and Aldosterone at the high top of the range (292 over a max of 295), despite my blood sodium and potassium were in range. I used gonadorelins to restart my HPTA, after 6 weeks I did a blood test again showing a testosterone at the same level pre TRT (286), LH/FSH restarted, Aldosterone still at the top of the range, ACTH still at 109, cortisol in range (16 over a range 7-19). Still, bloated and full of water retention, in particolar after a workput or after eating. I tried Eplenerone (25 mg and 50 mg), Metformine, Potassium... Nothing worked. I found this article about testosterone inhibiting 11 HSD2 therefore with cortisol binding MR. I think this is my case: testosterone in presence of high ACTH and realtively high cortisol made this cortisol binding MR and making me retaining water. There are now some questions: - how is it possible that my sodium/potassium in blood test are in range? - shouldn't I have high sodium and low potassium due to this activity on MR? - how long does it take for 11 HSD2 to reactivate and MR to unbind from cortisol? - there is something other I can do? Now I am 2 months off from my TRT but still bloated and full of water. Would very very thankful if some can give me your advice. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol
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