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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
WARNING: Propecia (finasteride) or Proscar can cause erection issues.
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<blockquote data-quote="Nelson Vergel" data-source="post: 7221" data-attributes="member: 3"><p>Highlights</p><p>· Post-finasteride patients show altered levels of neuroactive steroids.</p><p>· Post-finasteride patients show persistent sexual side effects.</p><p>· Post-finasteride patients show anxious/depressive symptomatology.</p><p></p><p></p><p><strong>Caruso D, Abbiati F, Giatti S, et al. Patients Treated for Male Pattern Hair with Finasteride Show, after Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma. J Steroid Biochem Mol Biol. <a href="http://www.sciencedirect.com/science/article/pii/S0960076014000831" target="_blank">http://www.sciencedirect.com/science/article/pii/S0960076014000831</a> </strong></p><p></p><p></p><p>Observations performed in a subset of patients treated for male pattern hair loss seem to indicate that persistent sexual side effects as well as anxious/depressive symptomatology were reported even after discontinuation of finasteride treatment.</p><p></p><p></p><p>Due to the capability of finasteride to block the metabolism of progesterone (PROG) and/or testosterone (T) we have evaluated, by liquid chromatography-tandem mass spectrometry, the levels of several neuroactive steroids in paired plasma and cerebrospinal fluid (CSF) samples obtained from post-finasteride patients and in healthy controls.</p><p></p><p></p><p>At the examination, post-finasteride patients referred muscular stiffness, cramps, tremors and chronic fatigue in the absence of clinical evidence of any muscular disorder or strength reduction.</p><p></p><p></p><p>Severity of the anxious/depressive symptoms were quite variable in their frequency, overall all the subjects had a fairly complex and constant neuropsychiatric pattern.</p><p></p><p></p><p>Assessment of neuroactive steroid levels in CSF show a decrease of PROG and its metabolites, dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), associated to an increase of its precursor pregnenolone (PREG).</p><p></p><p></p><p>Altered levels were also observed for T and its metabolites. Thus, a significant decrease of dihydrotestosterone (DHT) associated to an increase of T as well as of 3alpha-diol was detected.</p><p></p><p></p><p>Changes in neuroactive steroid levels also occurred in plasma. An increase of PREG, T, 3alpha-diol, 3beta-diol and 17beta-estradiol was associated to decreased levels of DHP and THP.</p><p></p><p></p><p>The present observations show that altered levels of neuroactive steroids, associated to depression symptoms, are present in androgenic alopecia patients even after discontinuation of the finasteride treatment.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 7221, member: 3"] Highlights · Post-finasteride patients show altered levels of neuroactive steroids. · Post-finasteride patients show persistent sexual side effects. · Post-finasteride patients show anxious/depressive symptomatology. [B]Caruso D, Abbiati F, Giatti S, et al. Patients Treated for Male Pattern Hair with Finasteride Show, after Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma. J Steroid Biochem Mol Biol. [URL]http://www.sciencedirect.com/science/article/pii/S0960076014000831[/URL] [/B] Observations performed in a subset of patients treated for male pattern hair loss seem to indicate that persistent sexual side effects as well as anxious/depressive symptomatology were reported even after discontinuation of finasteride treatment. Due to the capability of finasteride to block the metabolism of progesterone (PROG) and/or testosterone (T) we have evaluated, by liquid chromatography-tandem mass spectrometry, the levels of several neuroactive steroids in paired plasma and cerebrospinal fluid (CSF) samples obtained from post-finasteride patients and in healthy controls. At the examination, post-finasteride patients referred muscular stiffness, cramps, tremors and chronic fatigue in the absence of clinical evidence of any muscular disorder or strength reduction. Severity of the anxious/depressive symptoms were quite variable in their frequency, overall all the subjects had a fairly complex and constant neuropsychiatric pattern. Assessment of neuroactive steroid levels in CSF show a decrease of PROG and its metabolites, dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), associated to an increase of its precursor pregnenolone (PREG). Altered levels were also observed for T and its metabolites. Thus, a significant decrease of dihydrotestosterone (DHT) associated to an increase of T as well as of 3alpha-diol was detected. Changes in neuroactive steroid levels also occurred in plasma. An increase of PREG, T, 3alpha-diol, 3beta-diol and 17beta-estradiol was associated to decreased levels of DHP and THP. The present observations show that altered levels of neuroactive steroids, associated to depression symptoms, are present in androgenic alopecia patients even after discontinuation of the finasteride treatment. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
WARNING: Propecia (finasteride) or Proscar can cause erection issues.
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