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[URL unfurl="true"]https://vorck.com/erythrocytosis.html[/URL]The study is from 2014, the same year erythroferrone was discovered, which is the missing link here and the reason the connection between RBCs and hepcidin is vague in the link. Erythroferrone is produced by erythroblasts (immature RBCs) in response to erythropoietin (EPO) and it (Erythroferrone) acts directly on the liver to suppress hepcidin via the BMP6 pathway [Source]. Lower hepcidin means iron tends to flow out of cells and into hemoglobin. Here's that erythroferrone-hepcidin relationship explained [Source]
[URL unfurl="true"]https://vorck.com/erythrocytosis.html[/URL]
The study is from 2014, the same year erythroferrone was discovered, which is the missing link here and the reason the connection between RBCs and hepcidin is vague in the link. Erythroferrone is produced by erythroblasts (immature RBCs) in response to erythropoietin (EPO) and it (Erythroferrone) acts directly on the liver to suppress hepcidin via the BMP6 pathway [Source]. Lower hepcidin means iron tends to flow out of cells and into hemoglobin. Here's that erythroferrone-hepcidin relationship explained [Source]
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