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Vitamin D3
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<blockquote data-quote="Re-Ride" data-source="post: 42593" data-attributes="member: 8395"><p>25-hydroxycholecalciferol serum assay aka "25(OH)D" aka "25-hydroxy-D" coupled with knowledge of how effectively one personally processes cholcalciferol is all anyone needs to know when deciding on D3 supplementation. Not how much Joe or Guinevere had for lunch. </p><p></p><p> Once you know your baseline AND have identified a serum goal you can then, sort of, guestimate daily intake required to achieve that goal. Not everyone achieves the same serum level from the the same dosing. The only way to verify that you are moving in to a safer zone is with frequent serum testing. </p><p></p><p>There is an association of serum in the "safer zones" with: i) improved survival ii) fewer clinical manifestations of certain serious maladies. The association is strongly suggestive of but does not prove that higher OH-D-25 levels directly result in these clinical outcomes. Higher serum folks could be more vigilant in other areas of health or maybe they laugh more.</p><p></p><p> Test results in the U.S. are typically expressed in ng/ml. Elsewhere it's nmol/l. </p><p></p><p>The optimum OH-D-25 level is 45, 60, 75 or more depending on who you want to believe. The Vit D Council and the Endocrine Society both claim 40-50. One Canadian government site says 75. </p><p></p><p>As an example, I could not, after two years, get out of the single digits on 50k IU ergocalciferol (D2), the Rx synthetic D that Big Pharma likes to push. No amount of strong sun exposure made any difference either. 5k IU D3, then 10, then 15 then 20,000 per day and I gradually climbed to mid 40's. Raising OH-D-25 can be a long process taking a year or more. Most folks will do much better. But relying on averages is a poor approach as seen here.</p></blockquote><p></p>
[QUOTE="Re-Ride, post: 42593, member: 8395"] 25-hydroxycholecalciferol serum assay aka "25(OH)D" aka "25-hydroxy-D" coupled with knowledge of how effectively one personally processes cholcalciferol is all anyone needs to know when deciding on D3 supplementation. Not how much Joe or Guinevere had for lunch. Once you know your baseline AND have identified a serum goal you can then, sort of, guestimate daily intake required to achieve that goal. Not everyone achieves the same serum level from the the same dosing. The only way to verify that you are moving in to a safer zone is with frequent serum testing. There is an association of serum in the "safer zones" with: i) improved survival ii) fewer clinical manifestations of certain serious maladies. The association is strongly suggestive of but does not prove that higher OH-D-25 levels directly result in these clinical outcomes. Higher serum folks could be more vigilant in other areas of health or maybe they laugh more. Test results in the U.S. are typically expressed in ng/ml. Elsewhere it's nmol/l. The optimum OH-D-25 level is 45, 60, 75 or more depending on who you want to believe. The Vit D Council and the Endocrine Society both claim 40-50. One Canadian government site says 75. As an example, I could not, after two years, get out of the single digits on 50k IU ergocalciferol (D2), the Rx synthetic D that Big Pharma likes to push. No amount of strong sun exposure made any difference either. 5k IU D3, then 10, then 15 then 20,000 per day and I gradually climbed to mid 40's. Raising OH-D-25 can be a long process taking a year or more. Most folks will do much better. But relying on averages is a poor approach as seen here. [/QUOTE]
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