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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Vitamin D Supplementation and Testosterone
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<blockquote data-quote="madman" data-source="post: 179111" data-attributes="member: 13851"><p>[ATTACH=full]9788[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 2. </span>The active form of vitamin D (VitD) increases the expression of androgen metabolism enzymes (ie, P450scc, and SRD5A1). 25-Hydroxyvitamin D3 (1,25[OH]2D3) binds to its membrane receptor and consequently further binds to the nuclear receptor, forming the VitD receptor (VDR) retinoid X receptor (RXR) heterodimer. There are VitD-dependent genes in the nucleus, and when the VDR-RXR heterodimer is activated, the vitamin D response element (VDRE) signals the expression of androgen enzymes in the mitochondria. P450scc acts primarily on the hormone cascade, which is responsible for converting cholesterol into pregnenolone. After pregnenolone is synthesized, several enzymatic actions lead to testosterone formation, whose processes occur in the endoplasmic reticulum. Increased expression of SRD5A1 by virtue of 1,25(OH)2D3 signaling enhances the conversion of testosterone to dihydrotestosterone. The proposed pathway for the association between the active form of VitD and increased testosterone levels in humans occurs in the Leydig cells, whereas the association with increased levels of dihydrotestosterone occurs in cells that predominantly express isoforms of 5a-reductase, one of which is SRD5A1. Some precursors of the testosterone pathway should be investigated through randomized clinical trials for better clinical insight. DHEA, dehydroepiandrosterone.</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p></blockquote><p></p>
[QUOTE="madman, post: 179111, member: 13851"] [ATTACH type="full"]9788[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 2. [/COLOR]The active form of vitamin D (VitD) increases the expression of androgen metabolism enzymes (ie, P450scc, and SRD5A1). 25-Hydroxyvitamin D3 (1,25[OH]2D3) binds to its membrane receptor and consequently further binds to the nuclear receptor, forming the VitD receptor (VDR) retinoid X receptor (RXR) heterodimer. There are VitD-dependent genes in the nucleus, and when the VDR-RXR heterodimer is activated, the vitamin D response element (VDRE) signals the expression of androgen enzymes in the mitochondria. P450scc acts primarily on the hormone cascade, which is responsible for converting cholesterol into pregnenolone. After pregnenolone is synthesized, several enzymatic actions lead to testosterone formation, whose processes occur in the endoplasmic reticulum. Increased expression of SRD5A1 by virtue of 1,25(OH)2D3 signaling enhances the conversion of testosterone to dihydrotestosterone. The proposed pathway for the association between the active form of VitD and increased testosterone levels in humans occurs in the Leydig cells, whereas the association with increased levels of dihydrotestosterone occurs in cells that predominantly express isoforms of 5a-reductase, one of which is SRD5A1. Some precursors of the testosterone pathway should be investigated through randomized clinical trials for better clinical insight. DHEA, dehydroepiandrosterone. [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Vitamin D Supplementation and Testosterone
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