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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Vitamin D Supplementation and Testosterone
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<blockquote data-quote="madman" data-source="post: 179110" data-attributes="member: 13851"><p><strong>Reviewing the Evidence on Vitamin D Supplementation in the Management of Testosterone Status and Its Effects on Male Reproductive System (Testis and Prostate): <span style="color: rgb(184, 49, 47)">Mechanistically Dazzling but Clinically Disappointing </span></strong></p><p></p><p><span style="color: rgb(184, 49, 47)">Heitor O. Santos, RD ; Scott Howell, PhD ; Keith Nichols, MD ; and Filipe J. Teixeira, RD, PhD</span></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">ABSTRACT </span></strong></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>Purpose: </strong>Vitamin D supplementation has been suggested to increase testosterone levels. The primary purpose of this literature review was to critically assess the physiologic effects of vitamin D supplementation on serum testosterone concentrations in men and the secondary purpose was to evaluate the feasibility of vitamin D status toward urologic health (testis and prostate). </span></p><p><span style="color: rgb(0, 0, 0)"></span></p><p><span style="color: rgb(0, 0, 0)"><strong>Methods: </strong>A structured literature review was performed using the Cochrane, MEDLINE, and Web of Science databases. The literature search encompassed studies published between 2011 and 2019.<strong> </strong></span></p><p><span style="color: rgb(0, 0, 0)"><strong></strong></span></p><p><span style="color: rgb(0, 0, 0)"><strong>Findings: </strong>Observational studies suggest an association between higher testosterone and serum vitamin D concentrations. Conversely, most randomized clinical trials that investigated the effect of vitamin D administration on testosterone levels have failed to detect any significant effect. Physiologically, vitamin D is engaging in spermatogenesis, but it remains unclear whether vitamin D is a determinant of fertility. With prostate support, the management of vitamin D status has been associated with a decreased prevalence of benign prostatic hyperplasia and symptoms (ie, lower urinary tract symptoms). However, with prostate cancer, there is a paucity of evidence pertaining to vitamin D supplementation. </span></p><p></p><p><strong><span style="color: rgb(0, 0, 0)"><strong>Implications: </strong></span></strong><span style="color: rgb(184, 49, 47)"><strong>Mechanistically, vitamin D exhibits essential roles in the testis and prostate; </strong></span><span style="color: rgb(44, 130, 201)"><strong>otherwise, there is no apparent evidence to support the use of vitamin D supplementation to increase testosterone levels and to improve clinical outcomes related to the male reproductive system. </strong></span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>CONCLUSION </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>Mechanistically, VitD has several essential roles in various organs (eg, heart, muscle, bone, and gut), including organs of the male reproductive system, such as testis and prostate.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Thus far, despite physiologic importance of VitD in modulating the testicular steroidogenesis, there is no sound evidence for the use of VitD supplementation as a testosterone adjuvant, as detailed in this structured literature review. The evidence on VitD supplementation remains inconsistent in urologic conditions, particularly as an adjuvant to improve sperm and prostate parameters.</strong></span> Practitioners should refrain from any enthusiasm regarding VitD supplementation and 25(OH)D screening for urologic heath. <span style="color: rgb(26, 188, 156)"><strong>The evidence presented in this review represents another nail in the coffin for VitD as a magic bullet. </strong></span>Definitive long-term clinical trials are needed to confirm the effects of VitD supplementation on diseases critical to urologic health with an emphasis on hypogonadism, BPH, and prostate cancer.</p></blockquote><p></p>
[QUOTE="madman, post: 179110, member: 13851"] [B]Reviewing the Evidence on Vitamin D Supplementation in the Management of Testosterone Status and Its Effects on Male Reproductive System (Testis and Prostate): [COLOR=rgb(184, 49, 47)]Mechanistically Dazzling but Clinically Disappointing [/COLOR][/B] [COLOR=rgb(184, 49, 47)]Heitor O. Santos, RD ; Scott Howell, PhD ; Keith Nichols, MD ; and Filipe J. Teixeira, RD, PhD[/COLOR] [B][COLOR=rgb(184, 49, 47)]ABSTRACT [/COLOR][/B] [COLOR=rgb(0, 0, 0)][B]Purpose: [/B]Vitamin D supplementation has been suggested to increase testosterone levels. The primary purpose of this literature review was to critically assess the physiologic effects of vitamin D supplementation on serum testosterone concentrations in men and the secondary purpose was to evaluate the feasibility of vitamin D status toward urologic health (testis and prostate). [B]Methods: [/B]A structured literature review was performed using the Cochrane, MEDLINE, and Web of Science databases. The literature search encompassed studies published between 2011 and 2019.[B] Findings: [/B]Observational studies suggest an association between higher testosterone and serum vitamin D concentrations. Conversely, most randomized clinical trials that investigated the effect of vitamin D administration on testosterone levels have failed to detect any significant effect. Physiologically, vitamin D is engaging in spermatogenesis, but it remains unclear whether vitamin D is a determinant of fertility. With prostate support, the management of vitamin D status has been associated with a decreased prevalence of benign prostatic hyperplasia and symptoms (ie, lower urinary tract symptoms). However, with prostate cancer, there is a paucity of evidence pertaining to vitamin D supplementation. [/COLOR] [B][COLOR=rgb(0, 0, 0)][B]Implications: [/B][/COLOR][/B][COLOR=rgb(184, 49, 47)][B]Mechanistically, vitamin D exhibits essential roles in the testis and prostate; [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]otherwise, there is no apparent evidence to support the use of vitamin D supplementation to increase testosterone levels and to improve clinical outcomes related to the male reproductive system. [/B][/COLOR] [B]CONCLUSION [/B] [COLOR=rgb(184, 49, 47)][B]Mechanistically, VitD has several essential roles in various organs (eg, heart, muscle, bone, and gut), including organs of the male reproductive system, such as testis and prostate.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Thus far, despite physiologic importance of VitD in modulating the testicular steroidogenesis, there is no sound evidence for the use of VitD supplementation as a testosterone adjuvant, as detailed in this structured literature review. The evidence on VitD supplementation remains inconsistent in urologic conditions, particularly as an adjuvant to improve sperm and prostate parameters.[/B][/COLOR] Practitioners should refrain from any enthusiasm regarding VitD supplementation and 25(OH)D screening for urologic heath. [COLOR=rgb(26, 188, 156)][B]The evidence presented in this review represents another nail in the coffin for VitD as a magic bullet. [/B][/COLOR]Definitive long-term clinical trials are needed to confirm the effects of VitD supplementation on diseases critical to urologic health with an emphasis on hypogonadism, BPH, and prostate cancer. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Vitamin D Supplementation and Testosterone
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