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Vitamin D and Semen Quality: Disappointing Study Results
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<blockquote data-quote="CoastWatcher" data-source="post: 110090" data-attributes="member: 2624"><p>Many men with hypogonadism present with dramatically low levels of Vitamin D. Animal models and cross-sectional cohort studies suggest that Vitamin D may have a beneficial role in male reproduction. A randomized clinical set out to determine the effect of 25-hydroxyvittamin D and calcium supplementation on the semen quality of infertile men. The results were disappointing.</p><p> </p><ul> <li data-xf-list-type="ul">A total of 1427 infertile men were screened to include 330; 1002 men did not meet inclusion criteria and 95 did not wish to participate.</li> <li data-xf-list-type="ul">The active group received cholecalciferol 300,000 IU initially, then 1400 IU cholecalciferol and 500 mg of calcium daily for 150 days; the other group received placebo.</li> <li data-xf-list-type="ul">Serum concentrations of 25OHD and 1,25-dihydroxyvitamin D3 were significantly higher in men in the treatment group compared with the placebo group. </li> <li data-xf-list-type="ul"><strong>Vitamin D supplementation was not associated with changes in semen parameters, although spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group [7.3% vs 2.4%, &#916;5.0% (-0.6%; 10.5%)]. Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo [35.6% vs 18.3%, &#916;17.3% (1.6%; 32.9%)]. </strong></li> <li data-xf-list-type="ul"><strong>Moreover, serum inhibin B levels were higher in men deficient in vitamin D who were randomly assigned to receive high-dose vitamin D [193 pg/mL vs 143 pg/mL, &#916;49 pg/mL (8; 91 pg/mL)]; however, the increase in sperm concentration was not significantly higher than in the placebo group (P = 0.07). </strong></li> <li data-xf-list-type="ul"><strong>High-dose vitamin D supplementation did not improve semen quality in vitamin D-insufficient infertile men. </strong></li> <li data-xf-list-type="ul"><strong>The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D-deficient men may be of clinical importance and warrant verification by others. </strong></li> </ul><p>"Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial," <em>Journal of Clinical Endocrinology and Metabolism, </em>2018, <a href="https://www.ncbi.nlm.nih.gov/m/pubmed/29126319/" target="_blank">https://www.ncbi.nlm.nih.gov/m/pubmed/29126319/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 110090, member: 2624"] Many men with hypogonadism present with dramatically low levels of Vitamin D. Animal models and cross-sectional cohort studies suggest that Vitamin D may have a beneficial role in male reproduction. A randomized clinical set out to determine the effect of 25-hydroxyvittamin D and calcium supplementation on the semen quality of infertile men. The results were disappointing. [LIST] [*]A total of 1427 infertile men were screened to include 330; 1002 men did not meet inclusion criteria and 95 did not wish to participate. [*]The active group received cholecalciferol 300,000 IU initially, then 1400 IU cholecalciferol and 500 mg of calcium daily for 150 days; the other group received placebo. [*]Serum concentrations of 25OHD and 1,25-dihydroxyvitamin D3 were significantly higher in men in the treatment group compared with the placebo group. [*][B]Vitamin D supplementation was not associated with changes in semen parameters, although spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group [7.3% vs 2.4%, Δ5.0% (-0.6%; 10.5%)]. Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo [35.6% vs 18.3%, Δ17.3% (1.6%; 32.9%)]. [/B] [*][B]Moreover, serum inhibin B levels were higher in men deficient in vitamin D who were randomly assigned to receive high-dose vitamin D [193 pg/mL vs 143 pg/mL, Δ49 pg/mL (8; 91 pg/mL)]; however, the increase in sperm concentration was not significantly higher than in the placebo group (P = 0.07). [/B] [*][B]High-dose vitamin D supplementation did not improve semen quality in vitamin D-insufficient infertile men. [/B] [*][B]The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D-deficient men may be of clinical importance and warrant verification by others. [/B] [/LIST] "Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial," [I]Journal of Clinical Endocrinology and Metabolism, [/I]2018, [URL]https://www.ncbi.nlm.nih.gov/m/pubmed/29126319/[/URL] [/QUOTE]
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Vitamin D and Semen Quality: Disappointing Study Results
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