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I started with twice weekly injections and in all honesty twice weekly worked fine for me. I've never had any issue with estradiol levels. My issues was, I liked higher levels of testosterone and I had high HCT, donating blood every 8 weeks got tiring, I went to dailies to stop my high HCT and keep good T levels. I don't know if daily injections or being on TRT for 2 years stabilize my HCT but I haven't donated for over 1 1/2 years.
