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“Mass spectrometry is not a turnkey method,” Auchus said. “It is real people in the lab, running experiments on a day-to-day basis, getting funny results, and trying to repeat them again. Maybe we need to change the column; maybe we need to clean the instrument or replace a part or run some solvent through it over the weekend to clean it up. That is why you cannot necessarily get results one day. It is not the sensitivity that limits you. It is the noise that is the problem.”