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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Very long term TRT (20+ years) - risk of liver cancer?
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<blockquote data-quote="Cataceous" data-source="post: 247796" data-attributes="member: 38109"><p>Aside from having absorption issues, transdermal products might skew the ratio of androgenic to estrogenic activity. It depends in part on the amounts of 5α-reductase and aromatase in the skin. Scrotal application in particular is notorious for efficient conversion of testosterone to DHT. DHT is anti-estrogenic, reducing aromatization and also acting through competitive inhibition at estrogen receptors.</p><p></p><p>By the way, welcome to ExcelMale from another PeakTestosterone refugee! It's too bad we lost that site, but ExcelMale is also a great place to be.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 247796, member: 38109"] Aside from having absorption issues, transdermal products might skew the ratio of androgenic to estrogenic activity. It depends in part on the amounts of 5α-reductase and aromatase in the skin. Scrotal application in particular is notorious for efficient conversion of testosterone to DHT. DHT is anti-estrogenic, reducing aromatization and also acting through competitive inhibition at estrogen receptors. By the way, welcome to ExcelMale from another PeakTestosterone refugee! It's too bad we lost that site, but ExcelMale is also a great place to be. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Very long term TRT (20+ years) - risk of liver cancer?
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