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Message: <blockquote data-quote="madman" data-source="post: 123557" data-attributes="member: 13851">I would not stress about your e2 as you need the sensitive assay to truly see where your e2 sits and the standard test you had done tends to overestimate in men so just because you are posting a 285 pmol/L (reference range <162) does not mean your e2 is high.When I first started trt 2 months in after a dose increase 150 mg/week (75 mg every 3.5 days) injected strictly sub-q abdominal fat my TT trough 1000 + ng/dl and FT double top end range and at the time my e2 was tested using the standard assay and it was a whopping 256 pmol/L (reference range <162) and I have never experienced any high e2 symptoms.My SHBG was mid range pre-trt almost smack dab in the middle of the reference range.I do not use hcg and have never touched an aromatase inhibitor and am almost approaching 2 years into trt now.</blockquote>